Scientists reported that loganin directly targeted histidine triad nucleotide-binding protein 1 (HINT1) to alleviate depressive-like behaviors. Overexpression of HINT1 in the hippocampus induces depressive-like behaviors.
[Molecular Psychiatry]
Targeting HINT1 to Improve Synaptic Plasticity: Toward Loganin As a New Antidepressant Strategy
