Novel Selective Strategies Targeting the BCL-2 Family to Enhance Clinical Efficacy in ALK-Rearranged Non-Small Cell Lung Cancer

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Investigators found that dynamic BH3 profiling presented an excellent predictive capacity to anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors, that would facilitate their use in a clinical setting and complementing the readout of standard diagnostic assays.
[Cell Death & Disease]
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