Recapitulating Hypoxic Metabolism in Cartilaginous Organoids via Adaptive Cell-Matrix Interactions Enhances Histone Lactylation and Cartilage Regeneration

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Scientists engineered a cell-adaptable supramolecular hydrogel that accommodated the extensive volumetric and morphological changes of encapsulated mesenchymal stromal cells, facilitating the rapid formation of large multicellular cartilaginous organoids.
[Nature Communications]
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