USP25 Directly Interacts with and Deubiquitinates PPARα to Increase PPARα Stability in Hepatocytes and Attenuate High-Fat Diet-Induced MASLD in Mice

Analysis of mRNA profiling data showed that both human and mouse metabolic dysfunction-associated steatotic liver disease (MASLD) were associated with reduced expression of ubiquitin-specific peptidase 25 (USP25) in hepatocytes.