A Novel Human Fetal Lung-Derived Alveolar Organoid Model Reveals Mechanisms of Surfactant Protein C Maturation Relevant to Interstitial Lung Disease

Researchers described the development of mature, expandable alveolar type 2 (AT2) organoids derived from human fetal lungs which were phenotypically stable, could differentiate into AT1-like cells, and were genetically manipulable.