CPSF6-RARγ Interacts with Histone Deacetylase 3 to Promote Myeloid Transformation in RARG-Fusion Acute Myeloid Leukemia

Using the most prevalent retinoic acid receptor gamma (RARG) fusion, CPSF6-RARG (CR), as a representative, scientists revealed that the CR fusion, enhanced the expansion of myeloid progenitors, impaired their maturation and synergized with RAS mutations to drive more aggressive myeloid malignancies.