Calpain 2 Promotes Lenvatinib Resistance and Cancer Stem Cell Traits via Both Proteolysis-Dependent and Independent Approach in Hepatocellular Carcinoma

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Researchers employed integrated bioinformatic analysis to identify calpain-2 as a novel key regulator for Lenvatinib resistance in HCC, and its expression greatly increased in both Lenvatinib-resistant HCC cell lines and clinical samples.
[Molecular Biomedicine]
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