Selective Regulation of IFN-γ and IL-4 Co-Producing Unconventional T Cells by Purinergic Signaling

Scientists showed that MAIT, γδT, and NKT cells expressed P2RX7 and were sensitive to P2RX7-mediated cell death. Mouse peripheral T-bet+ MAIT1, γδT1, and NKT1 cells, especially in the liver, co-express ARTC2 and P2RX7.