KMT2A Regulates the Autophagy-GATA4 Axis Through METTL3-Mediated m⁶A Modification of ATG4a to Promote NPCs Senescence and IVDD Progression

Investigators observed impaired autophagy in Iitervertebral disc degeneration-nucleus pulposus cells (NPCs), which contributed to the upregulation of NPCs senescence and the senescence-associated secretory phenotype.