m⁶A-Modified SNRPA Controls Alternative Splicing of ERCC1 Exon 8 to Induce Cisplatin Resistance in Lung Adenocarcinoma

The authors identified SNRPA as a spliceosome-related gene that potentially modulated resistance to platinum chemotherapy. Both the knockout or the knockdown of SNRPA via CRISPR/Cas9 and shRNA techniques could reverse the resistance of cisplatin-resistant LUAD cells to cisplatin.