Eosinophils Mitigate Intestinal Fibrosis While Promoting Inflammation in a Chronic DSS Colitis Model and Co-Culture Model with Fibroblasts

Scientists stimulated fibroblasts with active eosinophils or with Eosinophil Cationic Protein (ECP), and assessed fibroblast activation via flow cytometry and immunocytochemistry. They observed decreased fibroblast activation when fibroblasts were co-cultured with active eosinophils or after stimulation with ECP in comparison to monoculture conditions.