Polyclonality Overcomes Fitness Barriers in Apc-Driven Tumorigenesis

Investigators combined multicolor lineage tracing with chemical mutagenesis in mice to show that a large proportion of intestinal tumours have a multiancestral origin. Polyclonal tumors retained a structure comprising subclones with distinct Apc mutations and transcriptional states, driven predominantly by differences in KRAS and MYC signalling.