Spatial Dimension Cues Derived From Fibrous Scaffolds Trigger Mechanical Activation to Potentiate the Paracrine and Regenerative Functions of MSCs via the FAK-PI3K/AKT Axis

The 3D fibrous constructs exhibiting well-defined topology with distinct spatial dimensions were fabricated using melt electro-writing to elucidate the effects of spatial dimension cues on the paracrine and regenerative functions of adipose-derived-MSCs.