Ascorbate Deficiency Increases Quiescence and Self-Renewal in Hematopoietic Stem Cells and Multipotent Progenitors

Scientists showed that deletion of the Slc23a2 ascorbate transporter from hematopoietic cells depleted ascorbate to undetectable levels in HSCs and multipotent hematopoietic progenitors without altering plasma ascorbate levels.