ALDH1A3 Is the Switch That Determines the Balance of ALDH⁺ and CD24⁻CD44⁺ Cancer Stem Cells, EMT-MET, and Glucose Metabolism in Breast Cancer

The authors found that aldehyde dehydrogenase 1A3 (ALDH1A3) regulates these cancer-promoting processes and the abundance of the two distinct breast CSC populations defined by high ALDH activity and CD24−CD44+ cell surface expression.