Epigenetic Therapy Potentiates Transposable Element Transcription to Create Tumor-Enriched Antigens in Glioblastoma Cells

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Researchers treated patient-derived primary glioblastoma stem cell lines, an astrocyte cell line, and primary fibroblast cell lines with epigenetic drugs, and identified treatment-induced, transposable element-derived transcripts preferentially expressed in cancer cells.
[Nature Genetics]
Abstract