Nanoparticle Delivery of Innate Immune Agonists Combined with Senescence-Inducing Agents Promotes T Cell Control of Pancreatic Cancer

Researchers investigated an immunotherapy approach combining delivery of stimulator of interferon genes and Toll-like receptor 4 innate immune agonists by lipid-based nanoparticle coencapsulation with senescence-inducing RAS-targeted therapies, which could remodel the immune suppressive PDAC tumor microenvironment through the senescence-associated secretory phenotype.