Promotion of Stem Cell-Like Phenotype of Lung Adenocarcinoma by FAM83A via Stabilization of ErbB2

Through a global proteomics analysis, the study identifies human epidermal growth factor receptor 2 as a crucial target of FAM83A. Mechanistically, FAM83A facilitated ErbB2 expression at the posttranslational modification level via the E3 ubiquitin ligase STUB1.