Targeting TGFβ-Activated Kinase-1 Activation in Microglia Reduces CAR T Immune Effector Cell-Associated Neurotoxicity Syndrome

Researchers examined the role of microglia using mouse models and cohorts of individuals with ICANS. CD19-directed CAR (CAR19) T cell transfer in B cell lymphoma-bearing mice caused microglia activation and neurocognitive deficits.