Endometrial Cancer PDX-Derived Organoids (PDXOs) and PDXs with FGFR2c Isoform Expression Are Sensitive to FGFR Inhibition

Researchers reported the establishment of 16 endometrial cancer (EC) PDXOs with or without FGFR2c expression. In vitro treatment of five EC PDXOs with BGJ398 showed significant cell death in three models with FGFR2c expression.