Intratumoral Androgen Biosynthesis Associated with 3β-Hydroxysteroid Dehydrogenase 1 Promotes Resistance to Radiotherapy in Prostate Cancer

Germline inheritance of the adrenally permissive allele confers worse outcomes in men with advanced prostate cancer. Scientists investigated whether HSD3B1 (1245C) drove resistance to combined androgen deprivation and radiotherapy.