NewslettersImmune Regulation News The Guanine Nucleotide Exchange Factor Rin-Like Controls Tfh Cell Differentiation via CD28 Signaling By Laurisa Dohm - September 15, 2023 0 260 Loss of the guanine nucleotide exchange factor Rin-like led to an increase of Tfh in aging, upon in vivo immunization and acute LCMV Armstrong infection in mice, and in human CD4+ T cell in vitro cultures. [Journal Of Experimental Medicine] Abstract