UHRF1 Inhibition Epigenetically Reprograms Cancer Stem Cells to Suppress the Tumorigenic Phenotype of Hepatocellular Carcinoma

By
lbeveridge
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0
197
Hepatocyte-specific Uhrf1 knockout (Uhrf1HKO) strongly suppressed tumor initiation and CSC self-renewal in both diethylnitrosamine (DEN)/CCl4-induced and Myc-transgenic hepatocellular carcinoma mouse models.
[Cell Death & Disease]
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