Lipin1 Plays Complementary Roles in Myofiber Stability and Regeneration in Dystrophic Muscles

Using a cell culture system, the authors found that lipin1 deficiency led to elevated expression levels of necroptotic markers and medium creatine kinase which could be due to sarcolemmal damage. Most importantly, restoration of lipin1 inhibited the elevation of necroptotic markers in differentiated primary lipin1-deficient myoblasts.