Transcriptome Profiling Reveals That VNPP433-3β, the Lead Next-Generation Galeterone Analog Inhibits Prostate Cancer Stem Cells by Downregulating Epithelial–Mesenchymal Transition and Stem Cell Markers

In this study using RNA-seq, cytological, and biochemical methods, scientists reported that VNPP433-3β inhibited prostate CSCs by targeting key pathways critical to stemness and epithelial–mesenchymal transition.