 | | Vol. 5.43 – 7 December, 2020 |
| |
|
|
| PAK4 knockout induced adhesion protein re-expression in endothelial cells, reduced vascular abnormalities, improved T cell infiltration and inhibits glioblastoma growth in mice.
[Nature Cancer] |
|
 |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists developed a standardized metric- the Endothelial Index- to estimate vascular density in over 10,000 human tumors, corresponding to 31 solid tumor types, from transcriptome data.
[Journal of Clinical Investigation] |
|
|
|
| Researchers showed that microRNA-223 (miR-223)–mediated regulation of N-glycan biosynthesis in endothelial cells (ECs) regulated endothelial-to-hematopoietic transition. MiR-223 was enriched in hemogenic endothelial cells and in oligopotent nascent hematopoietic stem and progenitor cells.
[Science] |
|
|
|
| Cardiac repair was analyzed in mice harboring specific endothelial or smooth muscle cells or cardiomyocyte or myeloid cell deficiency of indoleamine 2, 3-dioxygenase 1 and challenged with acute myocardial infarction.
[Circulation] |
|
|
|
| The authors report that in brain microvascular endothelial cells of patients suffering stroke, CLDN5 abnormally aggregated in the cytosol accompanied by autophagy activation. In vivo zebrafish and in vitro cell studies revealed that blood-brain barrier breakdown was partially caused by caveolin 1-mediated redistribution of membranous CLDN5 into the cytosol under hypoxia.
[Autophagy] |
|
|
|
| Investigators HMPL-013 inhibited VEGF/VEGFR2 binding in choroidal endothelial cells and macrophages, as well as macrophage M1 polarization. In vitro, noncontact coculture of human choroidal vascular endothelial cells and macrophages under hypoxia conditions was established.
[Cell Death & Disease] |
|
|
|
| Testing autocrine and paracrine effects in an avascular tumor spheroid growth assay, both exogenous monoacylglyceride-conjugated form of eicosapentaenoic acid and endogenous ω3 reduced VEGF secretion and in vitro endothelial cell tube formation and blocked tumor spheroid growth, suggesting that ω3 molecules could directly hinder prostate cancer cell growth.
[Molecular Cancer Research] |
|
|
|
| Scientists created the first 3D adipose tissue organoid model which could contain and maintain resident immune cell populations of the stromal vascular fraction and proved to be effective in studying adipose tissue biology in a convenient manner.
[Scientific Reports] |
|
|
|
| The authors focused on the development of new tissue-engineered vascular graft using a silk-based scaffold material for abdominal venous system replacement. A rat vein, the inferior vena cava, was replaced by a silk fibroin tissue-engineered vascular graft.
[Scientific Reports] |
|
|
|
| Investigators showed that autocrine cxcl12b/cxcr4 activity led to increased production of the vascular smooth muscle cells chemoattractant ligand pdgfb by endothelial cells in vitro and increased expression of pdgfb by arteries of zebrafish and mice in vivo.
[Communications Biology] |
|
 |
|
|
|
| Scientists review the literature pertaining to the contribution of endocardial cells to valvular, and nonvalvular lineages and highlight critical pathways required for these processes.
[Cold Spring Harbor Perspectives in Medicine] |
|
|
|
|
| EyePoint Pharmaceuticals, Inc. announced positive results from its good laboratory practice preclinical toxicology study of EYP-1901, a potential six-month sustained delivery intravitreal anti-VEGF treatment using its proprietary bioerodible Durasert® technology for wet age-related macular degeneration.
[EyePoint Pharmaceuticals, Inc.] |
|
|
|
| Bio-Thera Solutions announced that it has submitted the MAA for BAT1706, a proposed biosimilar to Avastin®, to EMA. Bio-Thera seeks a commercial license for all approved indications of bevacizumab in the European Union Member States, Iceland, Norway and Liechtenstein.
[Bio-Thera Solution] |
|
|
|
|
| May 30 – June 4, 2021
Castelldefels, Spain |
|
|
|
|
|
| | University of Buffalo – Buffalo, New York, United States |
|
|
|
| | Radboudumcy – Nijmegen, Netherlands |
|
|
|
| | Karolinska Institutet – Stockholm, Sweden |
|
|
|
| | Stanford University – Stanford, California, United States |
|
|
|
| | Universität Leipzig – Leipzig, Germany |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
