 | | Vol. 9.38 – 07 October, 2020 |
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| Researchers interrogated N6-methyladenosine (m5A) mRNA modifications in glioma stem cells by methyl RNA-immunoprecipitation followed by sequencing and transcriptome analysis, finding transcripts marked by m6A often upregulated compared to normal neural stem cells.
[Cancer Discovery] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators identified a specific glioblastoma multiforme stem-like cells subset and showed that activity of these cells was positively regulated by stabilization of methyl CpG binding domain 3 protein.
[Journal of Clinical Investigation] |
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| Extracellular matrix-rich tumors exhibited a stem cell-like gene expression profile and superior tumor-initiating capacity, whereas such features were absent in responder tumors.
[Cancer Immunology Research] |
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| Scientists observed that patient-derived glioblastoma cells expressing shRNAs of VEGF or neuropilin-1 attenuated cancer stem cell markers, inhibited the tumor-initiating cell’s neurosphere-forming capacity, and migration.
[Oncogene] |
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| Investigators demonstrated that knockout of RAB6 inhibited pulmonary fibrosis, oxidative stress, and type 2 alveolar epithelial cells (AEC2) cell death in fine particulate matter (PM2.5)-injured mice. In addition, knockout of RAB6 decreased Dickkopf 1 autocrine and activated proliferation, self-renewal, and wnt/β-catenin signaling of PM2.5-injured AEC2 cells.
[Cell Death & Disease] |
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| TGFβ1 rich secretome from Helicobacter pylori-reprogrammed fibroblasts prompted phenotypic plasticity and epithelial–mesenchymal transition (EMT) of gastric epithelium, inducing pro-neoplastic expansion of post-EMT cells in the presence of low TGFβR1 and TGFβR2 activity.
[Microorganisms] |
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| FT282, JHOS2 and OVCAR4 cells were transiently transfected with either single or pooled TIMP-2 siRNAs. The expression of different genes after TIMP-2 knock down or in response to chemotherapy was determined at the mRNA level by quantitative real time PCR and at the protein level by immunofluorescence.
[BMC Cancer] |
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| Scientists used aspirin, a nonselective COX inhibitor, with cisplatin for several hours in cells and days in vivo, and studied the inhibition against human cisplatin‐resistant H460 cells.
[Thoracic Cancer] |
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| This study displayed histological and immunohistochemical analyses of a malignant tumor model developed from cancer stem cells converted from human iPSCs in a cancer microenvironment prepared from the conditioned medium of a pancreatic cancer cell line.
[Acta Histochemica] |
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| Scientists discuss the relative dependency that acute myeloid leukemia (AML) cells have on mitochondrial function, and the ability to pivot this reliance to target important subsets of AML cells, including leukemia stem cells.
[Biochemical Pharmacology] |
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| The authors give an overview of the complex role of nucleolar and endoplasmic reticulum stress-response mechanisms in the regulation of autophagy in cancer and cancer treatment.
[International Journal of Molecular Sciences] |
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| Aprea Therapeutics, Inc. announced that the FDA has accepted the Company’s Investigational New Drug application for APR-548 to treat TP53 mutant myelodysplastic syndromes. APR-548 is a next-generation small molecule reactivator of mutant p53 that is being developed for oral administration.
[Aprea Therapeutics, Inc.] |
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| November 11 – November 13
Virtual |
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| | The University of Chicago – Location |
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| | The Mayo Clinic – Jacksonville, Florida, United States |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | The University of Georgia – Athens, Georgia, United States |
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| | Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
