Cancer Stem Cell News Volume 9.08 | Mar 04 2020

TOP STORY

An Absolute Human Stemness Index Associated with Oncogenic Dedifferentiation

Scientists provided an absolute relative expression orderings-based stemness index to evaluate the stemness. They found that this stemness index had higher correlation with the culture time of the differentiated stem cells than the previous stemness index. [Brief Bioinform] Abstract

(Ranked by impact factor of the journal)

ZHX2 Restricts Hepatocellular Carcinoma by Suppressing Stem Cell-Like Traits through KDM2A-Mediated H3K36 Demethylation

The tumor-initiating and chemoresistance properties of ZHX2-overexpressing and ZHX2-knockdown cells were analyzed in vivo and in vitro. [EBioMedicine] Abstract

Sphere-Forming Culture for Expanding Genetically Distinct Patient-Derived Glioma Stem Cells by Cellular Growth Rate Screening

Researchers constructed a novel high-throughput culture condition screening platform called ‘GFSCAN’, which evaluated the cellular growth rates of glioma stem cells for each diffusely infiltrating glioma sample in 132 serum-free combinations. [Cancers] Full Article

Circ-SOX4 Promotes Non-Small Cell Lung Cancer Progression by Activating the Wnt/β-Catenin Pathway

Subsequent functional assays showed that circ-SOX4 downregulation suppressed lung tumor-initiating cells proliferation, self-renewal, migration and invasion. [Mol Oncol] Abstract

Replication Protein A (RPA) Mediates Radio-Resistance of Glioblastoma Cancer Stem-Like Cells

Investigators showed that RPA was preferentially expressed by glioblastoma cancer stem-like cells and high RPA expression informed poor glioma patient survival. [Int J Mol Sci] Full Article

Infiltrating Macrophages Induced Stem-Cell-Like Features through PI3K/AKT/GSK3β Signaling to Promote Neurofibroma Growth

Infiltrating macrophages induced neurofibroma cell stem cell transition by modulating PI3K/AKT/GSK3β signaling, which then enhanced neurofibroma cell viability in vivo and in vitro. [Arch Med Res] Abstract

Puerarin 6″-O-Xyloside Suppresses Growth, Self-Renewal and Invasion of Lung Cancer Stem-Like Cells Derived from A549 Cells via Regulating Akt/C-Myc Signaling

Scientists enriched and identified a subpopulation of lung cancer stem-like cells derived from lung adenocarcinoma A549 cells with traits including high self-renewal and invasive capability in vitro. [Clin Exp Pharmacol Physiol] Abstract

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma Cancer Stem Cells

Two cell lines displayed stem-like characteristics like increase in the expression of ABCB1A, Nanog and Oct4 as well as an E-cadherin/N-cadherin switch. [Mol Biol Rep] Abstract

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The Role of Ubiquitination in Tumorigenesis and Targeted Drug Discovery

The authors summarize the latest progress in understanding the substrates for ubiquitination and their special functions in tumor metabolism regulation, tumor microenvironment modulation and cancer stem cell stemness maintenance. [Signal Transduct Target Ther] Full Article

Cancer Stem Cells: Devil or Savior-Looking behind the Scenes of Immunotherapy Failure

Scientists discuss the current scientific evidence linking cancer stem cell biological, immunological, and epigenetic features to tumor resistance to immunotherapy. [Cells] Full Article

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

VA Portland Health Care System Joins KIYATEC Clinical Study of Test to Predict Pre-Treatment, Patient-Specific Response to Glioblastoma Drugs

KIYATEC, Inc. announced that VA Portland Health Care System (VAPORHCS) has joined the growing roster of institutions participating in its 3D-PREDICT clinical study to validate the company’s test as a patient-specific predictor of response to cancer therapies for patients with glioblastoma. [KIYATEC, Inc.] Press Release

WPD Pharmaceuticals’ Annamycin Received Positive Interim Results from Phase I/II Clinical Studies in Acute Myeloid Leukemia

WPD’s license partner Moleculin Biotech, Inc. disclosed additional positive interim safety and efficacy data from one of the two ongoing open label, single arm Phase I/II studies of Annamycin for the treatment of relapsed or refractory AML. [WPD Pharmaceuticals Inc.] Press Release

China Bans Cash Rewards for Publishing Papers

Chinese institutions have been told to stop paying researchers bonuses for publishing in journals, as part of a new national policy to cut perverse incentives that encourage scientists to publish lots of papers rather than focus on high-impact work. [Nature News] Editorial

UC Santa Cruz Fires Graduate Students Taking Part in Strike

The University of California, Santa Cruz, fired 54 graduate student employees from their teaching positions on February 28, in the latest escalation of a months-long dispute over student pay, the Santa Cruz Sentinel reports. [The Scientist] Editorial

NEW First International STEMNET Meeting
May 6-8, 2020
Padua, Italy

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Breast Cancer Stem Cells (Albert Einstein College of Medicine)

NEW Research Fellow – Leukemia Stem Cell Biology (University College London)

Postdoctoral Scientist – Stem Cell Biology in Leukemia (University of Manchester)

Postdoctoral Fellow Position – RAS Cancer Cell Biology (University of Luxembourg)

Postdoctoral Researcher – Cancer Cell Invasiveness and Cancer Stem Cells (Cancer Research Center of Lyon)

Postdoctoral Associate – Glioma Stem Cell Biology (Cornell University)

Postdoctoral Research Fellowship – Cancer Biology and Stem Cell Biology (UT Southwestern Medical Center)

Postdoctoral Fellow – Translational Brain Tumor Research (Northwestern University)

Postdoctoral Studentship and PhD Position – Cancer Cell Plasticity (Giessen University)

Postdoctoral Position – Stemness in Epigenetic Regulation (University of Freiburg)

Postdoctoral Fellow – Research in Cancer Progression (The Wistar Institute)

Postdoctoral Position – Bioinformatics and Leukemia Stem Cells (The Centre for Genomic Regulation)

Postdoctoral Fellow – Clonal Evolution of Cancer (Moffitt Cancer Center & Research Institute)

Postdoctoral Position – Glioma and Neurodevelopment (Mount Sinai)

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