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Pulmonary Cell News| Cancer Stem Cell News 5.34 August 31, 2016 | |
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TOP STORYMulti-Organ Mapping of Cancer Risk Researchers used Cre-recombination of conditional lineage tracing, oncogene, and tumor suppressor alleles to define populations of stem and non-stem cells in mouse organs and test their life-long susceptibility to tumorigenesis. [Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML Comprehensive RNA sequencing and splice-isoform-specific PCR uncovered characteristic RNA splice isoform expression patterns that distinguished normal young and aged human stem and progenitor cells from malignant myelodysplastic syndrome and acute myeloid leukemia (AML) progenitors. [Cell Stem Cell] Abstract | Graphical Abstract TNIK Inhibition Abrogates Colorectal Cancer Stemness Investigators report the first orally available small-molecule Traf2- and Nck-interacting kinase (TNIK) inhibitor, NCB-0846, having anti-Wnt activity. X-ray co-crystal structure analysis reveals that NCB-0846 binds to TNIK in an inactive conformation, and this binding mode seems to be essential for Wnt inhibition. [Nat Commun] Full Article Recent work has divided glioma stem-like cells (GSC) into two subtypes with a mesenchymal (MES) GSC population as the more malignant subtype. Scientists identified the FOXD1-ALDH1A3 signaling axis as a determinant of the MES GSC phenotype. [Cancer Res] Abstract SOX9-Regulated Cell Plasticity in Colorectal Metastasis Is Attenuated by Rapamycin The authors showed that SOX9 levels are higher in metastatic than in primary colorectal cancer cells derived from the same patient. This elevated expression correlated with enhanced self-renewal activity. [Sci Rep] Full Article Researchers characterized the mammary epithelial stem/progenitor cells in the common marmoset. The age-associated mammary stem cell-enriched cells formed four major types of morphologically distinct colonies when cultured on plates pre-seeded with irradiated fibroblasts, and were also capable of forming mammospheres in suspension culture and subsequent formation of 3D organoids in Matrigel culture. [Sci Rep] Full Article Crucial Role of HMGA1 in the Self-Renewal and Drug Resistance of Ovarian Cancer Stem Cells Scientists investigated the role of HMGA1, a chromatin remodeling factor abundantly expressed in many different cancers, in the regulation of cancer stem cells in ovarian cancer. [Exp Mol Med] Full Article Calreticulin Is Highly Expressed in Pancreatic Cancer Stem-Like Cells The authors aimed to identify a biomarker of pancreatic cancer stem-like cells (P-CSLCs). P-CSLC-enriched population was generated from pancreatic cancer cell lines using their previously reported method and its protein expression profile was compared with that of parental cells by two-dimensional electrophoresis and tandem mass spectrometry. [Cancer Sci] Abstract Expression of Natural Killer Cell Regulatory MicroRNA by Uveal Melanoma Cancer Stem Cells Cancer stem cells enriched from aggressively metastatic MUM2B uveal melanoma cells by selecting CD271+ cells or propagating as non-adherent spheres in stem-cell supportive were more resistant to natural killer cell cytolysis than cancer stem cells enriched from less aggressively metastatic OCM1 uveal melanoma cells. [Clin Exp Metastasis] Abstract | |
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REVIEWSCancer Stem Cells in Human Gastrointestinal Cancer The reviewers focus on the current research on gastrointestinal cancer stem cells (CSCs) and future strategies to abolish the gastrointestinal CSC phenotype. [Cancer Sci] Abstract The authors focus on the innovative treatment methods such as nano-, immuno-, gene-, and chemotherapy approaches for targeting cancer stem cells-specific markers and/or their associated signaling pathways. [Tumor Biol] Abstract Visit our reviews page to see a complete list of reviews in the cancer stem cell research field. | |
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INDUSTRY NEWSBiocept, Inc. announced a preferred provider agreement with Teneovita Medical, a division of Teneovita Medical Innovations, Inc. Under the agreement, Teneovita will market and distribute Biocept’s Target Selector™ liquid biopsy testing services to major cancer hospitals, individual oncology practices, and integrative oncology centers. [Biocept, Inc.] Press Release Varian Expands Access to Advanced Cancer Care in Bolivia Varian Medical Systems announced the installation of a Clinac® iX medical linear accelerator at Instituto Oncologico del Oriente Boliviano in Santa Cruz, Bolivia. First patient treatments were started earlier in August. [Varian Medical Systems] Press Release Oncternal Therapeutics Initiates Patient Dosing in Phase I Clinical Trial of TK216 in Ewing Sarcoma Oncternal Therapeutics, Inc. announced that the first patient has been dosed in a Phase I clinical trial of TK216 in Ewing sarcoma. TK216 is a small molecule therapeutic candidate that inhibits the biological activity of ets-family transcription factor oncoproteins, which are the main disease drivers in Ewing tumors. [Oncternal Therapeutics, Inc.] Press Release The Everett Clinic Announces Leadership Transitions The Everett Clinic announced two transitions among its senior leadership. Rick Cooper will be the northwest regional market president for DaVita HealthCare Partners and Chris Knapp will be The Everett Clinic’s chief executive officer. [The Everett Clinic] Press Release | |
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POLICY NEWSHow DNA Could Store All the World’s Data Modern archiving technology cannot keep up with the growing tsunami of bits. But nature may hold an answer to that problem already. [Nature News Feature] Editorial Efforts to reduce irreproducibility in research must also tackle the temptation to cheat, argue Donald S. Kornfeld and Sandra L. Titus. [Nature Comment] Editorial China Tackles Antimicrobial Resistance China, the world’s largest consumer of human and animal antibiotics, has pledged to step up research and development into new antimicrobials and to rein in overuse of existing medicines to counter growing global antimicrobial resistance. [ScienceInsider] Editorial How Research and Policy Can Team to Change the World It takes much more than dedication inside the laboratory to overcome cancer. Only by working together with academic, political, and industry leaders toward the same goal can we successfully overcome this enormous medical obstacle. [Cell Press] Editorial
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EVENTSNEW Cell & Gene Therapy Bioprocessing & Commercialization Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Laboratory Studies Brain Cancer Stem Cells (Houston Methodist) Associate Scientist – Epigenetics of Cancer (Celgene Corporation) Full Professor – Molecular Mechanisms of Tumorigenesis (German Cancer Research Center) Postdoctoral Position – Metastatic Breast Cancer (Purdue Center for Cancer Research) Core Staff Scientist (Moffitt Cancer Center) Tenure Track Faculty – Biological Sciences Scholars Program (University of Michigan) Postdoctoral Fellow – Cancer Stem Cell Biology (Cleveland Clinic Lerner Research Institute) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Cancer Stem Cell News Volume 5.34 | Aug 31 2016
