 | | Vol. 12.40 – 1 November, 2023 |
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| Investigators demonstrated that impaired bromodomain-containing protein 9 (BRD9) function reduced the self-renewal capacity of human embryonic stem cells and altered their differentiation potential.
[Nucleic Acids Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To target tumor-initiating cells (TICs) to prevent recurrence, researchers identified genes critical for TIC viability from a whole genome siRNA screen. A top hit was the cancer-associated, proteoglycan subunit synthesis enzyme UDP-glucose dehydrogenase (UGDH).
[Journal Of Experimental & Clinical Cancer Research] |
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| Researchers identified a novel zinc finger protein X-linked (ZFX)/WNT3 axis that modulated the growth and imatinib mesylate response of chronic myeloid leukemia stem/progenitor cells.
[Cellular & Molecular Biology Letters] |
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| The authors analyzed a large number of human breast tissues for their basal and luminal cell composition with flow cytometry and their stem and progenitor cell function with sphere formation assay with respect to age and menopausal status in connection with a clinical study.
[Breast Cancer Research] |
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| 5-Fluorouracil (5-FU) caused DNA damage and ABT-888 enhanced the accumulation of the DNA lesions by inhibiting the mismatch repair repair pathway in 5-FU-pre-treated MMR-proficient-colorectal cancer-CSCs. This resulted in S-phase arrest, induction of apoptosis, and finally CSCs death.
[Expert Opinion On Therapeutic Targets] |
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| Investigators studied the molecular mechanism underlying the role of AS602801 in the treatment of brain metastasis in breast cancer. They utilized female athymic BALB/c nude mice and MDA-MB-231/BT-474BR cells to establish experimental models.
[Drug Development Research] |
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| Researchers investigated the circulating tumor cells (CTC) phenotypes and their prognostic implications in stage III/IV colorectal cancer. Patients who were diagnosed with CRC and underwent CTC detection at two hospitals were included.
[Scientific Reports] |
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| Uroplakin1B (UPK1B) was overexpressed or knocked down in the non-small cell lung cancer cells were. Next, the proliferation and invasion of those cells were detected with the EdU staining and transwell assays.
[Tissue And Cell] |
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| Cell blocks produced from lung adenocarcinoma patients’ pleural effusion were examined for cancer stem cell-related markers Nanog and CD133 using immunocytochemistry.
[Cytopathology] |
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| The authors summarize published data that reveal Snail proteins not only as key inducers of the epithelial-to-mesenchymal transition in ovarian cancer but also as crucial links between the acquisition of ovarian cancer stem properties and spheroid formation.
[Biochimica Et Biophysica Acta-Reviews On Cancer] |
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| Scientists discuss the key principles of deregulation of epigenetic processes that shape leukemia stem cells’ evolution. They also discuss efforts to identify mechanisms of resistance, by longitudinal analysis of patient samples.
[Molecular Oncology] |
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| City of Hope® and TGen are leading an international group that has been awarded $4.5 million to validate a liquid biopsy for the early detection of pancreatic cancer.
[City of Hope] |
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| A new experimental approach to treating pancreatic cancer is progressing to the next step in making it available to more patients. After results from a small study, a phase II clinical trial has now opened to test the effectiveness of using an mRNA vaccine to fight one of the deadliest cancers.
[Memorial Sloan Kettering Cancer Center] |
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| December 1 – 3, 2023
Chicago, Illinois, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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