 | | Vol. 12.45 – 6 December, 2023 |
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| Investigators showed SPINK1 to strongly associate with CD133 + hepatocellular carcinoma and tumor dedifferentiation.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Ellagic acid inhibited stemness maintenance by suppressing the hedgehog pathway, while Cu2+ further decreased stemness features of tumor cells by disrupting mitochondrial metabolism, effectively enhancing doxorubicin-mediated chemotherapy.
[Small] |
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| Scientists developed a stem cell factor SOX9-based reporter for isolating CSCs in primary tumors and metastases of spontaneous mammary tumor models.
[Science Advances] |
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| Investigators found that increased RAB27B in leukemia stem cells prevented their senescence and maintained their stemness in vitro and in vivo.
[Leukemia] |
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| Scientists explored novel miRNA–mRNA regulatory mechanisms that contribute to osimertinib resistance in lung cancer. They found that miR-204 expression in osimertinib-resistant lung cancer cells was markedly reduced compared to that in osimertinib-sensitive parental cells.
[Molecular Therapy – Nucleic Acids] |
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| Researchers demonstrated that the expression of sine oculis homeobox homolog 1 (SIX1) varied among different subtypes of breast cancer and that it upregulated breast cancer grading and lymph node metastasis.
[Journal of Translational Medicine] |
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| Loss- and gain-of-function experiments were utilized to assess the biological effects of METTL3 and SOCS3 on the proliferation and stemness phenotypes in vitro and in vivo.
[Cancer Gene Therapy] |
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| Scientists examined how elevated extracellular periostin, as they found was present in recurrent ovarian cancer (OC), impacted OC cell functions and phenotypes, including stemness.
[Scientific Reports] |
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| Researchers determined the phenotypic and therapeutic relevance of tumor microenvironment in neurofibroma type I (NF1) patients. Tumor stem cells from NF1 were isolated and cultured using fluorescence-activated cell sorting and colony formation experiments.
[Translational Oncology] |
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| The authors highlight the factors within the CSC niche that have important roles in regulating CSC properties, including the extracellular matrix, stromal cells, cancer-associated fibroblasts, mesenchymal stem cells, and physiological changes.
[Cancer Cell International] |
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| AbbVie announced that the company will pay $10 billion to the biotech firm Immunogen for the acquirement of an approved treatment for ovarian cancer and buying into a burgeoning area of oncology.
[STAT] |
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| February 14 – 18, 2024
Cancun, Mexico |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Jinfeng Labs & Institute of Functional Genomics – Chongqing, China |
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| | Westlake University – Zhejiang, China |
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| | Swammerdam Institute for Life Sciences – Amsterdam, Netherlands |
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| | Babraham Institute – Cambridge, England, United Kingdom |
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