 | | Vol. 12.28 – 19 July, 2023 |
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| A pan-cancer transcriptomic screening for 10852 samples of 33 TCGA cancer types revealed that cAMP-responsive element transcription factors were convergent activators for cancer stemness.
[Signal Transduction And Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using a murine acute myeloid leukemia (AML) model, human AML cell lines, and patient samples, scientists showed that AML leukemia-initiating stem cells were sensitive to endogenous and exogenous cyclopentenone prostaglandin-J, Δ12-PGJ2, and 15d-PGJ2.
[Cell Reports] |
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| Tumor tissues from oral squamous cell carcinoma patients were assessed for protein expression by immunohistochemistry. Patient survival was evaluated by Kaplan–Meier curve analysis.
[Journal Of Translational Medicine] |
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| Scientists found that Rab11-family interacting protein 4 (FIP4) was dramatically increased in HCC cell lines and tissues, and had a positive correlation with cancer stemness.
[Journal Of Physiology And Biochemistry] |
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| Investigators showed CBX4 was a critical regulator of the CSC phenotype in squamous cell carcinomas of the skin and hypopharynx. Moreover, Cancer associated fibroblasts could promote the expression of CBX4 in the CSC population through secretion of IL-6.
[Carcinogenesis] |
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| The authors sequentially treated colorectal cancer cells with activin and hepatocyte growth factor and examined CSC marker expression, self-renewal, tumorigenesis, and metastasis.
[Gut and Liver] |
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| In response to glucose starvation, the levels of β-catenin and stemness-related genes were upregulated in gastric CSCs (gCSCs), while the levels of β-catenin declined in GCICs.
[Molecules And Cells] |
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| Gene expression profiles were extracted from the Gene Expression Omnibus database and mRNA expression data were downloaded from The Cancer Genome Atlas database. In addition, TIMER 2.0 database was used to analyze the expression of genes in normal and multiple tumor tissues.
[Oncology Reports] |
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| Researchers found that NF-κB Inducing Kinase (NIK) level was upregulated in hepatocellular carcinoma tissues compared to that of normal tissues, and positively correlated with the levels of CSC markers.
[Environmental Toxicology] |
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| Head and neck cancer cells belonging to the stem cell population are distinguished by the high expression of certain surface proteins, pluripotency-related transcription factors, and increased activity of aldehyde dehydrogenase. Chemotherapy itself increases the percentage of stem-like cells.
[Journal Of Cancer Research And Clinical Oncology] |
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| The cancer-research arm of the World Health Organization has classified the low-calorie sweetener aspartame as ‘possibly carcinogenic’. The International Agency for Research on Cancer in Lyon, France, said its decision, announced on 14 July, was based on limited evidence for liver cancer in studies on people and rodents.
[Nature] |
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| In an effort to discover new treatments for brain tumors, such as glioblastoma, the Ivy Brain Tumor Center at Barrow Neurological Institute, announced the initiation of a ground-breaking Phase 0 clinical trial that tests a new experimental drug delivery method called superselective intra-arterial infusion, or SSIAI.
[Ivy Brain Tumor Center] |
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| September 27 – 30, 2023
Boston, Massachusetts, United States |
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| | Aarhus University – Aarhus, Denmark |
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| | Duke University – Durham, North Carolina, United States |
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| | City of Hope – Duarte, California, United States |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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| | The Hospital of the University of Munich – Munich, Germany |
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