 | | Vol. 12.02 – 17 January, 2023 |
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| Scientists reported that lysophosphatidic acid receptor 4 (LPAR4) became transiently upregulated on pancreatic cancer cells exposed to environmental stress or chemotherapy, promoting stress tolerance, drug resistance, self-renewal, and tumor initiation.
[Nature Cell Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators revealed that increased matrix stiffness was associated with poor responses to neoadjuvant chemotherapy, worse prognosis, and CSC enrichment in patients with breast cancer.
[Nature Communications] |
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| Researchers identified isoform 1 of the neurogenesis-associated protein ASPM as a prominently upregulated stemness-associated gene during the self-renewal of small cell lung cancer cells.
[Cancer Research] |
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| The authors reported the overexpression of YTHDF1, an m6A reader protein, in human acute myeloid leukemia samples at the protein level with enrichment in leukemia stem cells.
[Cancer Research] |
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| Researchers identified a novel circRNA named circNCAPG that was overexpressed and indicated poor prognosis in glioma patients. Upregulating circNCAPG promoted the malignant progression of glioma stem cells.
[Cell Death & Disease] |
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| Scientists identified a YAP1 tyrosine phosphorylation-dependent YAP1-Kruppel-like factor 5 (KLF5) oncogenic module, as the key downstream mediator of SRC kinase regulating cancer stemness and metastasis in triple-negative breast cancer.
[Cellular And Molecular Life Sciences] |
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| Polypyrimidine tract binding protein 1 (PTBP1) maintained the tumorigenic activity and stem-cell characteristics of gastric cancer in vitro and in vivo.
[British Journal Of Cancer] |
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| The authors explored the effectiveness of short micropeptides SC-301 and SC-401 on CSC properties, epithelial-mesenchymal transition, apoptosis, and autophagy in ovarian CSCs enriched from PA-1 and SKOV-3 cell lines.
[Life Sciences] |
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| Transcriptome profiling of epithelial-specific ‘normal’ CD133+ cells isolated from fetal and regenerating liver against ‘HCC’ CD133+ cells isolated from proto-oncogene driven and inflammation-associated HCC revealed preferential overexpression of SERPINA12 in HCC but not fetal and regenerating liver CD133+ cells.
[Hepatology] |
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| Scientists review how leukemia remodels the niche and rewires its metabolism with particular attention paid to therapy-resistant stem cells.
[Blood] |
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| Investigators review the contribution of different epigenetic regulatory mechanisms and some of the main effects of epigenetic-modulating agents in pediatric nervous system tumor CSCs.
[Molecular and Cellular Biochemistry] |
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| New medicines need not be tested in animals to receive FDA approval, according to legislation signed by President Joe Biden in late December 2022.
[ScienceInsider] |
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| April 14 – 19, 2023
Orlando, Florida, United States |
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| | Cancer Research Center of Lyon – Lyon, France |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Stanford Medicine – Stanford, California, United States |
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Cancer Stem Cell News
Cell Therapy News
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ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
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