 | | Vol. 11.11 – 23 March, 2022 |
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| Scientists illustrated that HIF-2α, but not HIF-1α, induced stemness in breast cancer cells under hypoxia through SOD2-mtROS-PDI/GRP78-UPRER pathway, linking mitochondrial metabolic state to endoplasmic reticulum (ER) response via mitochondrial reactive oxygen species (mtROS) level.
[Cell Death & Differentiation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Depletion of glycosyltransferase 8 domain containing 1 (GLT8D1) inhibited self-renewal of glioma stem cells in vitro and repressed tumor growth in glioma mouse models.
[Cell Death & Differentiation] |
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| The authors tested if inhibition of DOT1L, an epigenetic regulator of normal tissue stem/progenitor populations, would target triple-negative breast cancers stem cells.
[Clinical Cancer Research] |
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| Investigators found that acute myeloid leukemia (AML) cells obtained from relapsed patients had increased autophagy levels than de novo AML cells.
[Haematologica] |
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| Scientists showed that the expression of up-frameshift mutant 1 (UPF1) was upregulated in endometrial cancer tissues and endometrial CSCs and correlated with poor clinicopathological characteristics.
[Cell Death & Disease] |
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| 4’,5,7-trihydroxyisoflavone probe was a new chemical probe inhibitor of signal transducer and activator of transcription 1 (STAT1) that reduced stemness and angiogenesis in colorectal cancer.
[Journal of Biomedical Science] |
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| Researchers reported that macrophages, upon interaction with breast cancer cells, activated tumor promoting functions and exhibited differential expression of various proteins as shown by secretome analysis using proteomics studies.
[Cancer Cell International] |
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| Investigators performed GEO dataset analysis and identified that claudin1 was a critical regulator of epidermal growth factor receptor tyrosine kinase inhibitors resistance in non-small cell lung cancer (NSCLC) cells.
[Cell Death Discovery] |
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| Scientists identified downregulated long noncoding RNA (lncRNA) growth arrest-specific 5 (GAS5) in prostate cancer that was associated with metastasis and paclitaxel resistance.
[Asian Journal of Andrology] |
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| Researchers showed that immune-checkpoint blockade (ICB) therapy selected for ligand-dependent corepressor (LCOR) low CSCs with reduced antigen processing/presentation machinery driving immune escape and ICB resistance in triple-negative breast cancer.
[Nature Cancer] |
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| Scientists highlight the biological features, clinical application, and the therapeutic potential of circulating tumor cells (CTCs) and CTC clusters using single-cell analysis platforms for cancer management.
[Trends in Biotechnology] |
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| Investigators suggest that hypoxia-induced autophagy and CSCs proliferation should be elucidated in order to find a novel cure to defeat cancer cells.
[Molecular Biology Reports] |
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| The authors indicate that GD3 synthase contributes to gefitinib resistance in epidermal growth factor receptor-positive breast cancer cells, and is a potentially useful therapeutic target in drug-resistant breast cancers.
[Glycoconjugate Journal] |
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| AIM ImmunoTech, Inc. announced it has received notification from the FDA that the FDA’s Clinical Hold on AIM’s investigational new drug (IND) application for a Phase II study of Ampligen as a therapy for locally advanced pancreatic cancer has been lifted and the company may proceed with the study.
[AIM ImmunoTech Inc.] |
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| Wugen, Inc. announced that the first patient has been dosed in a Phase I/II trial of WU-CART-007 for the treatment of relapsed or refractory (R/R) T cell acute lymphoblastic leukemia (T-ALL)/lymphoblastic lymphoma (LBL).
[Wugen, Inc.] |
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| April 8-13, 2022
New Orleans, Louisiana, United States |
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| | CRUK Manchester Institute – Manchester, United Kingdom |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | Gilead Sciences – Foster City, California, United States |
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| | Oregon Health and Science University – Portland, Oregon, United States |
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| | University of Virginia School of Medicine – Charlottesville, Virginia, United States |
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Cancer Stem Cell News
Cell Therapy News
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