 | | Vol. 10.29 – 28 July, 2021 |
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| Scientists demonstrated that afatinib induced mTORC1 suppression-mediated autophagy in head and neck squamous cell carcinoma cells.
[Cell Death & Disease] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| In high invasive progeny cells from mouse glioma stem cells (GSCs) and a GSC-bearing mouse glioma model, researchers assessed the anti-tumor effects of sonodynamic therapy with a COX-2 inhibitor, celecoxib.
[Scientific Reports] |
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| Scientists demonstrated that NAD+ metabolism enabled acute myeloid leukemia (AML) to evade apoptosis. They integrated whole-genome CRISPR screening and pan-cancer genetic dependency mapping to identify NAMPT and NMNAT1 as AML dependencies governing NAD+ biosynthesis.
[Science Advances] |
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| Investigators identified a previously unrecognized role of the pro-autophagy factor AMBRA1 in regulating medulloblastoma .
[Acta Neuropathologica] |
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| Researchers evaluated TLR3-mediated activation of anti-tumor pathway based in RARβ expression, on As-CSC and iAs-transformed epithelial cells (CAsE-PE)
[Toxicology Letters] |
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| Scientists showed a new role for ETV7, a transcriptional repressor member of the ETS family, in promoting breast cancer stem-like cells plasticity and resistance to chemo- and radiotherapy in breast cancer cells.
[Cell Death & Disease] |
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| The authors investigated the role of acetylsalicylic acid in chemotherapy/chemoprevention in human oesophageal squamous cell carcinoma (ESCC) cell lines and an N-nitrosomethylbenzylamine-induced rat ESCC carcinogenesis model.
[British Journal of Cancer] |
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| Scientists silenced two autophagy related genes -either Beclin1 or ATG5- by shRNA and they explored the ensuing consequences on CSCs markers’ expression and functionalities.
[Aging-Us] |
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| Investigators demonstrated that CRISPR-mediated knockout of miR-200c induced metabolic features similar to the metabolic rewiring caused by p53 hot-spot mutations, and that impairing this metabolic reprogramming interfered with miR-200c deficiency-induced stemness and transformation.
[Molecular Cancer Research] |
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| The authors describe the immunological features of the acute myeloid leukemia (AML) niche, with particular attention to the crosstalk between the AML blasts and the cellular components of the altered tumor microenvironment and the mechanisms of immune escape that hamper the therapeutic effects of the most advanced treatments.
[Leukemia] |
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| Eureka Therapeutics, Inc. announced the initiation of a Phase I/II clinical trial of ECT204, a glypican 3 (GPC3) targeting ARTEMIS® T-cell therapy for the treatment of hepatocellular carcinoma, the predominant type of liver cancer.
[Eureka Therapeutics, Inc.] |
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| Kronos Bio, Inc. announced the US FDA has cleared its Investigational New Drug Application for LANRA, allowing the company to proceed with a Phase I/II clinical trial of LANRA in patients with relapsed or refractory FLT3-mutated AML in combination with gilteritinib.
[Kronos Bio, Inc.] |
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| The California stem cell agency awarded $51 million to help train students in the art of research at the Golden State’s community colleges and universities.
[Capitol Weekly] |
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| November 29 – December 1, 2021
Barcelona, Spain |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | Dalhousie University – Halifax, Nova Scotia, Canada |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Princess Margaret Cancer Centre – Toronto, Ontario, United States |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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