Neural Cell News
Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
Brain Aging and Rejuvenation at Single-Cell Resolution
[Neuron] Researchers review insights gleaned from single-cell omics studies of brain aging, starting with a cell-type-centric overview of age-associated changes and followed by a discussion of cell-cell interactions during aging.
Mapping the Developmental Trajectory of Human Astrocytes Reveals Divergence in Glioblastoma
[Nature Cell Biology] Researchers delineated the course of human astrocyte maturation to uncover discrete developmental stages and attributes mirrored by glioblastoma. They generated a transcriptomic and epigenomic map of human astrocyte maturation using cortical organoids maintained in culture for nearly two years.
Comprehensive Characterization of the Transcriptional Landscape in Alzheimer’s Disease (AD) Brains
[Science Advances] Scientists comprehensively characterized the landscape of noncoding RNAs (ncRNAs) and posttranscriptional modification (PTM) events in 1460 samples across six brain regions. They additionally identified 25,351 aberrantly expressed ncRNAs and altered PTM events associated with AD traits.
Nuclear Receptor PPARγ Targets GPNMB to Promote Oligodendrocyte Development and Remyelination
[Brain] Scientists identified PPARγ as an enriched transcription factor in the dysfunctional oligodendrocyte precursor cells (OPCs) accumulated in CNS demyelinated lesions. Its expression increased during OPC differentiation and myelination and was closely related to the process of CNS demyelination/remyelination.
Lecanemab-Associated Amyloid-β Protofibril in Cerebrospinal Fluid Correlates with Biomarkers of Neurodegeneration in Alzheimer’s Disease
[Annals of Neurology] Researchers aimed to characterize amyloid-β (Aβ) protofibril (PF) captured by lecanemab in human cerebrospinal fluid from living participants with different stages in Alzheimer's Disease, which enabled an enhanced understanding of the dynamic changes of lecanemab-associated Aβ-PF in vivo.
Aberrant Splicing in Huntington’s Disease Accompanies Disrupted TDP-43 Activity and Altered m6A RNA Modification
[Nature Neuroscience] Scientists identified TDP-43 and the N6-methyladenosine (m6A) writer protein METTL3 to be upstream regulators of exon skipping in multiple Huntington’s disease systems.
Monocyte-Derived Macrophages Act as Reinforcements When Microglia Fall Short in Alzheimer’s Disease
[Nature Neuroscience] The authors describe the conditions under which the microglia fall short, focusing mainly on the context of Alzheimer’s disease, and shed light on the functions performed by monocyte-derived macrophages.
Mucin5AC Promotes Breast Cancer Brain Metastasis Through cMET/CD44v6
[Clinical Cancer Research] In-silico dataset analysis, RNA-sequence profiling on patients and cell lines, analysis of patients’ serum samples, and in vitro and in vivo knockdown experiments were performed to determine the function of Mucin 5AC (MUC5AC) in breast cancer brain metastasis.
Anti-Herpetic Tau Preserves Neurons via the cGAS-STING-TBK1 Pathway in Alzheimer’s Disease
[Cell Reports] Researchers detected herpes simplex virus 1 (HSV-1)-associated proteins in human brain samples. Expression of the herpesvirus protein, immediate-early infection cell protein, increased with Alzheimer’s disease severity and strongly colocalized with p-tau but not with Aβ.
Maternal Phthalates Exposure Promotes Neural Stem Cell Differentiation into Phagocytic Astrocytes and Synapse Engulfment via IRE1α/XBP1s Pathway
[Cell Reports] Scientists demonstrated that maternal exposure to monobutyl phthalate enhanced neural stem cell differentiation into astrocytes with highly expressed C3 and LCN2 in mouse offspring, resulting in increased synapse phagocytosis and cognitive dysfunction.
Vascularized Human Brain Organoids: Current Possibilities and Prospects
[Trends In Biotechnology] Although vascularized hBOs (vhBOs) are already used to model (defects in) neurovascular development, vascularization efficiency and other outcomes differ substantially between vascularization protocols and overall shortcomings should be considered.
pH-Responsive Polyethylene Glycol Engagers for Enhanced Brain Delivery of PEGylated Nanomedicine to Treat Glioblastoma
[ACS Nano] To further boost brain uptake of PEGylated nanomedicine, scientists engineered a pH-responsive anti-polyethylene glycol (PEG) × anti-transferrin receptor bispecific antibody platform, in which the pH-responsive anti-PEG arm could bind to PEG in a pH-dependent manner.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
