Neural Cell News
Neural Cell News is an online resource covering the latest research in neuroscience, neural stem cells, and neurological conditions.
Transcriptomic Neuron Types Vary Topographically in Function and Morphology
[Nature] To uncover the cell-type architecture of the tectum, scientists transcriptionally profiled its neurons, revealing more than 60 cell types that were organized in distinct anatomical layers.
Thalamic Opioids from POMC Satiety Neurons Switch On Sugar Appetite
[Science] Investigators discovered that pro-opiomelanocortin (POMC) neurons not only promoted satiety in fed conditions but concomitantly switched on sugar appetite, which drove overconsumption.
Krüppel-Like Factor 9 Alleviates Alzheimer’s Disease via IDE-Mediated Aβ Degradation
[Acta Pharmacologica Sinica] Scientists revealed that global Krüppel-like factor 9 (Klf9)-mutant mice exhibited impaired cognitive function. Additionally, they found that Klf9 expression in hippocampal tissue was reduced in APPswe/PS1dE9 mice.
Stepwise Activation of SARM1 for Cell Death and Axon Degeneration Revealed by a Biosynthetic NMN Mimic
[Proceedings of The National Academy of Sciences of The United States of America] Investigators reported the identification of a potent proactivator of SARM1, G10, which was converted into a direct activator by the enzyme nicotinamide phosphoribosyltransferase.
Transcriptional Enhancers in Human Neuronal Differentiation Provide Clues to Neuronal Disorders
[EMBO Reports] Researchers employed a human mesencephalic neuronal cell differentiation model, LUHMES, with sensitive and high-resolution methods to discover enhancers, perform DNA conformation analysis to link enhancers to their target genes, and finally validate selected interactions.
Phenotypic Rescue via mTOR Inhibition in Neuron-Specific Pten Knockout Mice Reveals AKT and mTORC1-Site Specific Changes
[Molecular Psychiatry] Researchers generated a novel neuron-specific Pten knock-out mouse model to test the ability of pharmacologic mTOR inhibition to rescue Pten mutation-associated disease phenotypes in vivo and in vitro.
Antisense Oligonucleotide–Mediated MSH3 Suppression Reduces Somatic CAG Repeat Expansion in Huntington’s Disease iPSC–Derived Striatal Neurons
[Science Translational Medicine] Investigators showed that an MSH3-targeting antisense oligonucleotide effectively engaged with its RNA target in induced pluripotent stem cell (iPSC)–derived striatal neurons obtained from a patient with Huntington’s disease carrying 125 huntingtin CAG repeats.
Loss of ATG7 in Microglia Impairs UPR, Triggers Ferroptosis, and Weakens Amyloid Pathology Control
[Journal of Experimental Medicine] Researchers found that microglia-specific deletion of autophagy-related (Atg) 7 in an Alzheimer's disease mouse model impaired microglia coverage of Aβ plaques, increasing plaque diffusion and neurotoxicity.
GPR37L1 Identifies Spinal Cord Astrocytes and Protects Neuropathic Pain after Nerve Injury
[Neuron] Through single-nucleus RNA sequencing, the authors identified Gpr37l1 as a selective G-protein-coupled receptor marker for spinal cord astrocytes.
The Dynamic Axon Initial Segment: From Neuronal Polarity to Network Homeostasis
[Neuron] Scientists highlight the functions of the axon initial segment, its architecture, and how its organization and remodeling are influenced by developmental plasticity and both acute and chronic adaptations.
IPI Receives Grant from Chan Zuckerberg Initiative to Develop Next-Generation Protein Tools for Neuroscience Research
[The Institute for Protein Innovation] The Institute for Protein Innovation (IPI) announced that it received a $500,000 grant from the Chan Zuckerberg Initiative to develop innovative protein-based tools for neuroscience research.
Heat-Shock Chaperone HSPB1 Mitigates Poly-Glycine-Induced Neurodegeneration via Restoration of Autophagic Flux
[Autophagy] Scientists explored the role of the small molecular chaperone HSPB1 in counteracting neurodegeneration induced by poly-glycine aggregates.
Neural Cell News helps scientists keep pace with the latest research, reviews, and industry developments in neuroscience. Specific research topics include neural development and neuroregeneration, neural signaling related to cellular responses and behavior, and synaptic plasticity. Research into the diagnosis, progression, cellular characteristics, and treatment of brain diseases such as Parkinson’s, Multiple Sclerosis, Alzheimer’s, Amyotrophic Lateral Sclerosis and various brain cancers, as well as brain damage resulting from infection, trauma, stroke, seizures, and tumors, is also covered.
