Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
A Proof-of-Concept Study in Small and Large Animal Models for Coupling Liver Normothermic Machine Perfusion with Mesenchymal Stromal Cell Bioreactors
[nature communications] To fully harness MSCs’ benefits during Normothermic Machine Perfusion (NMP), researchers developed an advanced NMP platform coupled with a MSC-bioreactor and investigated its bio-molecular effects and clinical feasibility using rat and porcine models.
The Effects of Ultrasound-guided Corticosteroid Injection Compared to Mesenchymal Stem Cell Injection in Patients with Grade II and III Knee Osteoarthritis: A Randomized Double-blind...
[American Journal of Physical Medicine & Rehabilitation] Researchers investigated the effects of a single dose injection of MSCs under ultrasound guidance for knee osteoarthritis.
Extracellular Fluid Viscosity Regulates Human Mesenchymal Stem Cell Lineage and Function
[Science Advances] Scientists established fluid viscosity as a key physical cue that imprinted osteogenic memory in human MSCs and promoted an immunosuppressive phenotype.
Targeting the Tumor Microenvironment with Mesenchymal Stem Cells Based Delivery Approach for Efficient Delivery of Anticancer Agents: An Updated Review
[Biochemical Pharmacology] The authors provide an overview of the therapeutic use of MSCs as drug carriers, including a detailed analysis of the mechanisms by which MSCs deliver therapeutics to cancer cells, enabling targeted drug delivery.
Nasal Mucosal Mesenchymal Stem Cells Promote Repair of Sciatic Nerve Injury in Rats by Modulating the Inflammatory Microenvironment
[Neuroscience Letters] In vitro, ectodermal mesenchymal stem cells were found to enhance M2 macrophage polarization and the production of anti-inflammatory factors.
Developmental Dynamics Mimicking Inversely Engineered Pericellular Matrix for Articular Cartilage Regeneration
[Biomaterials] Investigators demonstrated the feasibility of using a pericellular matrix-mimicking system to improve MSC chondrogenesis and the efficacy of articular cartilage repair.
Long-Term Effect and Safety of Mesenchymal Stromal Cell Therapy for Radiation-Induced Hyposalivation in Head and Neck Cancer Survivors: A Randomised, Phase-II, Trial
[Clinical Cancer Research] The long-term effect of adipose-derived mesenchymal stromal cells to restore radiation-induced salivary gland hypofunction in previous head and neck cancer patients was investigated.
Msx1-Modified Rat Bone Marrow Mesenchymal Stem Cell Therapy for Rotator Cuff Repair: A Comprehensive Analysis of Tendon-Bone Healing and Cellular Mechanisms
[Journal of Orthopaedic Research] Scientists suggested that Msx1 modification enhances BMSC-mediated repair by promoting cell proliferation and migration, facilitating tendon-bone integration.
Biodegradable PHBVHHx-PEG/Collagen Hydrogel Scaffolds for Cartilage Repair
[Tissue Engineering Part A] Researchers demonstrated that PHBVHHx-COL scaffolds loaded with peripheral blood-derived MSCs significantly promoted the repair of cartilage injury through immune regulation by M2 polarization and could be potential candidates for cartilage tissue engineering.
Galvanic Cell-Stimulated Mesenchymal Stem Cell Mesh for Enhanced Pelvic Organ Prolapse Treatment
[Advanced Healthcare Materials] A fully degradable mesh is designed for the treatment of pelvic organ prolapse, utilizing MSCs stimulated by a galvanic battery-powered electric field.
Depleting Chemoresponsive Mitochondrial Fission Mediator DRP1 Does Not Mitigate Sarcoma Resistance
[Life Science Alliance] Scientists demonstrated that the expression and activation of the mitochondrial fission mediator dynamin-related protein 1 (DRP1) were affected by chemotherapy exposure in common pediatric sarcomas, namely, rhabdomyosarcoma and osteosarcoma.
Clinical Challenges in Bone Tissue Engineering – a Narrative Review
[Bone] The authors emphasize the impact of patient-specific factors on bone healing outcomes and the importance of personalized approaches. .
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
