Mesenchymal Cell News
Mesenchymal Cell News is an online resource that delivers updates on the latest research in the mesenchymal stem cell field.
Terumo Blood and Cell Technologies Partners with South Korea’s KBIOHealth to Help Develop Nation’s Cell and Gene Therapy Workforce
[Terumo BCT] Terumo Blood and Cell Technologies (Terumo BCT) signed a memorandum of understanding with Osong Medical Innovation Foundation toward joint development of workforce training for cell and gene therapy manufacturing. The partners will begin by creating programs to support the manufacture of MSC and chimeric antigen (CAR) T cell therapies.
Arsenic and Metabolic Diseases: New Insights from Mesenchymal Stem Cells
[Toxicology and Applied Pharmacology] The authors summarize the recent research progress on the role of MSCs in arsenic-related metabolic diseases.
Revolutionizing Bone Healing: The Role of 3D Models
[Cell Regeneration] Scientists report on the evolution of in vitro culture models applied to the study of bone healing/regrowth, starting from 2 to 3D cultures and microfluids.
Nature Cell’s JointStem Becomes the First Korean Company to Acquire Breakthrough Therapy Designation from the US FDA
[Nature Cell Co, Ltd. (ACCESS Newswire)] Nature Cell Co., Ltd., announced that JointStem has been granted Breakthrough Therapy Designation from the US FDA- the first instance for a Korean company in the field of cell therapy. JointStem is distinguished as the world's first autologous adipose-derived MSC therapy intended for patients with knee osteoarthritis.
Soft Pneumatic Device Designed to Mimic the Periosteal Environment for Regulating the Fate of Mesenchymal Stem Cells
[Advanced Healthcare Materials] Cell differentiation was reported using a spatial geometric platform that could periodically modulate complex mechanical forces through a custom-made soft pneumatic device to mimic the interfaces between periosteum and interstitial fluid.
Cellular Sentinels: Empowering Survival and Immune Defense in Hematopoietic Stem Cell Transplantation through Mesenchymal Stem Cells and T Lymphocytes
[BMC Medicine] Scientists explored the combined infusion of allotype-cord blood hematopoietic stem cells and activated T cells from the same donor along with third-party MSCs.
Human Umbilical Cord-Derived Mesenchymal Stem Cells Improve Thymus and Spleen Functions in D-Galactose-Induced Aged Mice
[Scientific Reports] Researchers investigated the potential of umbilical cord MSCs to mitigate d-galactose-induced immune senescence by enhancing the structural and functional integrity of aging immune organs and regulating the gut microbiota.
YAP1 Is a Key Regulator of EWS::FLI1-Dependent Malignant Transformation upon IGF-1-Mediated Reprogramming of Bone Mesenchymal Stem Cells
[Cell Reports] Investigators reported that transient exposure to insulin-like growth factor (IGF)-1 concentrations mimicking serum levels during puberty reprogrammed limb-derived mesenchymal cells of EWS::FLI1-mutant mice to stable transformation and tumorigenicity.
Organelle-Tuning Condition Robustly Fabricates Energetic Mitochondria for Cartilage Regeneration
[Bone Research] The authors demonstrated a highly efficient mitochondria-producing strategy by manipulating mitobiogenesis and tuning organelle balance in human MSCs.
Depletion of SUN1/2 Induces Heterochromatin Accrual in Mesenchymal Stem Cells during Adipogenesis
[Communications Biology] Researchers tested the hypothesis that severing of the nucleoskeleton and cytoskeleton complex-mediated cytoskeletal connections may have different effects on chromatin organization and MSC differentiation than those due to ablation of Sad1 and UNC-84 (SUN) proteins.
Adhesion-Assisted Antioxidant-Engineered Mesenchymal Stromal Cells for Enhanced Cardiac Repair in Myocardial Infarction
[ACS Nano] Investigators demonstrated that chemical modification of MSCs with anti-VCAM1 and polydopamine significantly enhanced MSC survival and promoted cardiac repair.
Aged and BRCA Mutated Stromal Cells Drive Epithelial Cell Transformation
[Cancer Discovery] Scientists reported that an epigenetically altered MSC niche, termed high risk MSC, existed prior to serous tubal intraepithelial carcinoma lesion formation.
Mesenchymal Cell News covers topics such as the isolation, identification, and culturing conditions of mesenchymal stem cells, as well as their cellular characterization, behavior and differentiation capacities. We also include research that focuses on identifying tissue sources of mesenchymal stem cells and their potential therapeutic applications in regenerative medicine and cellular therapies.
