Mammary Cell News
Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.
Molecular Classification of Hormone Receptor-Positive /HER2-Positive Breast Cancer Reveals Potential Neoadjuvant Therapeutic Strategies
[Signal Transduction and Targeted Therapy] Investigators conducted molecular typing on a cohort of 211 patients with HR+/HER2+ breast cancer and performed a comprehensive analysis of the efficacy of various neoadjuvant treatment regimens.
Ultrasound-Responsive Nanobubbles for Breast Cancer: Synergistic Sonodynamic, Chemotherapy, and Immune Activation through the cGAS-STING Pathway
[ACS Applied Materials & Interfaces] The authors explored the development of ultrasound-responsive nanobubbles for targeted imaging and sonoimmunotherapy in breast cancer treatment.
Selective Degradation of FGFR1/2 Overcomes Antiestrogen Resistance in ER+ Breast Cancer with FGFR1/2 Alterations
[Cancer Letters] Researchers investigated the selective degradation of FGFR1/2 using the proteolysis-targeting chimera DGY-09-192 as a novel therapeutic strategy in ER+ breast cancers harboring FGFR1/2 somatic alterations.
Impact of Endocrine Therapy Regimens for Early-Stage ER+/HER2-Breast Cancer on Contralateral Breast Cancer Risk
[NPJ Breast Cancer] Scientists adapted an established Cancer Intervention and Surveillance Network model to simulate life histories of multiple US female birth-cohorts diagnosed with stage 0-III ER+/HER2- breast cancer receiving different durations of two endocrine therapy regimens.
O-GlcNAcylation on Serine 40 of Histone H2A Promotes Proliferation and Invasion in Triple-Negative Breast Cancer
[Scientific Reports] Scientists showed that serine 40 of histone H2A was modified by O-GlcNAcylation levels, which were significantly higher in triple-negative breast cancer than in the other breast cancer subtypes.
Prognosis Model of Patients with Breast Cancer Based on Metabolism-Related LncRNAs
[Discover Oncology] Researchers identified metabolism-related lncRNAs with high predictive value for prognosis and constructed a model that can predict the prognosis of breast cancer individually.
Clinician’S Guide: Expert Insights on the Use of CDK4/6 Inhibitors in Patients with Early Breast Cancer
[Therapeutic Advances In Medical Oncology] The authors explore the integration of adjuvant CDK4/6 inhibitors into clinical practice, focusing on disease-free survival and safety outcomes.
Susan G. Komen® Urges Swift Passage of Reintroduced SCREENS for Cancer Act
[Susan G. Komen] Susan G. Komen® commended members of the US House and Senate for reintroducing the Screening for Communities to Receive Early and Equitable Needed Services (SCREENS) for Cancer Act.
Targeting PI3K Inhibitor Resistance in Breast Cancer with Metabolic Drugs
[Signal Transduction and Targeted Therapy] Using in vitro and orthotopic xenograft mouse models, scientists demonstrated that constitutively active mTORC1 signaling rendered PI3K inhibitor-resistant breast cancer exquisitely sensitive to various drugs targeting cancer metabolism.
MAGL Targeted PROTAC Degrader Simultaneously Enhances P53 for Synergistic Treatment of Glioblastoma Stem Cell
[Cell Death Discovery] Researchers presented a proof-of-concept PROTAC design tailored for glioblastoma (GBM) stem cells, potentially addressing the occurrence challenges for GBM.
PNO1 Enhances Ovarian Cancer Cell Growth, Invasion, and Stemness via Activating the AKT/Wnt/β-catenin Pathway
[Scientific Reports] The authors demonstrated that PNO1 silencing markedly reduced the proliferation and invasion capabilities of ovarian cancer cell lines, triggering their apoptosis.
Unraveling the Triad of Hypoxia, Cancer Cell Stemness, and Drug Resistance
[Journal of Hematology & Oncology] Investigators elucidate the interplay between hypoxia and CSCs, as well as their correlation with resistance to therapeutic drugs.
For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.
