Immunology of Infectious Disease News
Immunology of Infectious Disease News is an online resource dedicated to covering the latest research and developments in the field of infectious diseases.
Avian TRIM13 Attenuates Antiviral Innate Immunity by Targeting MAVS for Autophagic Degradation
[Autophagy] Scientists identified the duck Anas platyrhynchos domesticus TRIM13 as a novel negative regulator of duck MAVS that mediated the antiviral innate immune response.
The Intestinal Microbiome and Cetobacterium somerae Inhibit Viral Infection through TLR2-Type I IFN Signaling Axis in Zebrafish
[Microbiome] Researchers used a rhabdoviral infection model in zebrafish, which allowed them to investigate the modes of action of microbiome-mediated antiviral effect.
Rapid Biphasic Decay of Intact and Defective HIV DNA Reservoir during Acute Treated HIV Disease
[Nature Communications] Leveraging >500 longitudinal samples from 67 people living with HIV treated during acute infection, researchers developed a mathematical model to predict reservoir decay from peripheral CD4+ T cells.
Mycobacterium tuberculosis Antigen Rv1471 Induces Innate Immune Memory and Adaptive Immunity against Infection
[Journal of Infectious Diseases] Scientists tested Rv1471, a thioredoxin secreted by mycobacterium tuberculosis, as a candidate tuberculosis vaccine antigen due to its capacity to stimulate mouse bone marrow-derived macrophages.
TET2 Regulates Early and Late Transitions in Exhausted CD8+ T Cell Differentiation and Limits CAR T Cell Function
[Science Advances] In chronic lymphocytic choriomeningitis virus infection, TET2 drove conversion from stem cell–like TEX progenitors toward terminally differentiated and effector (TEX)–like TEX.
Plant-Produced SARS-CoV-2 Antibody Engineered Towards Enhanced Potency and In Vivo Efficacy
[Plant Biotechnology Journal] Investigators described the expression, production, and purification of the originally human COVA2-15 antibody in plants. Their plant-produced mAbs demonstrated comparable neutralizing activity with COVA2-15 produced in mammalian cells.
Altered Leukocyte Pattern and Inflammatory Markers in Unvaccinated Long COVID Patients: A Cross-Sectional Study
[Scientific Reports] Researchers suggested that Long Covid patients may exhibit alterations in inflammatory markers, indicating a persistently pro-inflammatory microenvironment that tends to diminish after 12 months of Long Covid.
Global Epidemiology of Meningococcal Disease-Causing Serogroups before and after the COVID-19 Pandemic: A Narrative Review
[Infectious Diseases and Therapy] Global invasive meningococcal disease declines during the pandemic were followed by resurgences generally caused by serogroups that were prevalent pre-pandemic and affecting mainly unvaccinated age groups.
GeoVax Announces Positive Interim Data Review for Phase II Clinical Trial of COVID-19 Vaccine Booster in Patients with Chronic Lymphocytic Leukemia
[GeoVax Labs, Inc.] GeoVax Labs, Inc. announced the completion of an interim data review by the Data Safety Monitoring Board for the ongoing Phase II clinical trial of GEO-CM04S1, GeoVax’s dual-antigen next-generation COVID-19 vaccine, as a booster vaccine for patients with chronic lymphocytic leukemia.
Immunometabolic Effect of Nitric Oxide on Human Macrophages Challenged With the SARS-CoV2-Induced Cytokine Storm. A Fluxomic Approach
The contribution of exogenously added NO, via a chemical NO-donor, on the immunometabolic changes associated with the SARS-CoV2-induced cytokine storm was investigated.
[Advanced Healthcare Materials]
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Safety of Simultaneous vs Sequential mRNA COVID-19 and Inactivated Influenza Vaccines: A Randomized Clinical Trial
Scientists compared the reactogenicity, safety, and changes in health-related quality of life after simultaneous vs sequential receipt of messenger RNA COVID-19 vaccine and quadrivalent...
Interleukin 17 Producing T Cell Responses in Human Chronic Trichinellosis-Insight from a Case Study
[Cytokine] Researchers studied the cellular immune response in a patient infected since 10 months during a trichinellosis outbreak caused by Trichinella spp.
Immunology of Infectious Disease News was founded to keep the scientific community current with the latest developments in infectious disease research. We feature high-impact publications, news, jobs, and events focused on immune responses to and the development of treatments for infectious diseases such as COVID-19, HIV, hepatitis, tuberculosis, influenza, and malaria.
