Human Immunology News
Human Immunology News is an online publication and email newsletter for researchers studying the human immune system.
Human Immune Organoids to Decode B Cell Response in Healthy Donors and Patients with Lymphoma
[Nature Materials] Researchers developed synthetic hydrogels mimicking the lymphoid tissue microenvironment, enabling human germinal centres from tonsils and peripheral blood mononuclear cell-derived B cells.
Inhibition of Cbl-B Restores Effector Functions of Human Intratumoral NK Cells
[Journal of Immunotherapy of Cancer] Investigators conducted a high-throughput screen to identify molecules that could enhance primary human NK cell function. After compound validation, they investigated the effect of the top-performing compounds on dysfunctional NK cells that were generated by a newly developed in vitro platform.
Quantitative Pharmacology of Dual-Targeted Bicistronic CAR-T-Cell Therapy Using Multiscale Mechanistic Modeling
[CPT-Pharmacometrics & Systems Pharmacology] Scientists developed a multiscale cellular kinetic–pharmacodynamic model using case studies from CD19/CD22 and GPRC5D/BCMA autologous CAR-Ts.
Natural Killer Cells Are Required for the Recruitment of CD8+ T Cells and the Efficacy of Immune Checkpoint Blockade in Melanoma Brain Metastases
[Journal of Immunotherapy of Cancer] Researchers demonstrated that NK cells underpin the efficacy of combined PD-1/CTLA-4 blockade in brain metastases by orchestrating the "responder" molecular profile in tumors, and by controlling the intratumoral abundance of CD8+ T cells through regulation of multiple key molecular mediators of T cell trafficking.
Environmental Triggers and Future Risk of Developing Autoimmune Diseases: Molecular Mechanism and Network Toxicology Analysis of Bisphenol A
[Ecotoxicology and Environmental Safety] Investigators advanced network toxicology strategies to efficiently investigate the putative toxicity and underlying molecular mechanisms of environmental pollutants, focusing on autoimmune diseases induced by bisphenol A exposure.
Full-Length RNA-Seq of the RHOH Gene in Human B Cells Reveals New Exons and Splicing Patterns
[Scientific Reports] To further understand the transcription events associated with this gene, scientists performed full-length RNA-Seq on 12 B-cell lines. They identified new exons, new splice events and new splice sites, leading to the discovery of 38 RHOH mRNA molecules, 27 of which have never been described before.
Schistosoma Heamatobium Tetraspanins TSP-2 and TSP-6 Induce Dendritic Cells Maturation, Cytokine Production and T Helper Cells Differentiation In Vitro
[Microbes and Infection] The authors investigated the role of Sh-TSP-2, Sh-TSP-6 and Sh-TSP-23, which were expressed in the parasite’s tegument and extracellular vesicles. Immature dendritic cells from unexposed healthy donors were stimulated with these proteins to evaluate maturation maker expression and cytokine production.
Immune Checkpoint Expression on Tumor-Infiltrating Lymphocytes (TIL) Is Dependent on HPV Status in Oropharyngeal Carcinoma (OPSCC) – a Single-Cell RNA Sequencing Analysis
[Oral Oncology] Scientists investigated differential immune checkpoint molecule (ICM) expression by HPV status using RNA sequencing data to identify additional ICM targets that may complement anti-PD1 antibodies.
Inducing and Regulating Human Naive CD4+ T Cell Proliferation by Different Antigen Presenting Cells
[Journal of Immunological Methods] Investigators tested different antigen presenting cells isolated from controls, CD19+ B cells, CD11c+CD14+ and CD11c+CD14neg monocytes, CD11c+CD14negCD16+ and CD16neg dendritic cells.
lncRNA-Mediated Immune System Dysregulation in RIF; a Comprehensive Insight into Immunological Modifications and Signaling Pathways’ Dysregulation
[Human Immunology] Given the apparent involvement of the immune system in recurrent implantation failure (RIF) and the modulatory effect of lncRNAs on the immune system, the authors aim to delve into the role of lncRNAs in immune system modulation and their potential contribution to RIF.
Quell Therapeutics Achieves Milestone for Type 1 Diabetes CAR-Treg Cell Therapy Program
[Quell Therapeutics, Ltd. (Globe Newswire)] Quell Therapeutics, Ltd. announces that AstraZeneca has selected a candidate to progress in the Type 1 Diabetes Treg cell therapy program.
Antibody Blockade of the PSGL-1 Immune Checkpoint Enhances T Cell Responses to B Cell Lymphoma
[Leukemia] Researchers investigated the potential of P-selectin glycoprotein ligand-1 (PSGL-1) antibody targeting in B cell lymphoma. Using allogeneic co-culture systems, they demonstrated that targeted antibody interventions against human PSGL-1 enhanced T cell activation and effector cytokine production in response to lymphoma cells.
Each issue of Human Immunology News provides up-to-date coverage of the latest news in immunology research performed using human cells or subjects. Our expert editors hand-pick recent research papers and review articles from relevant high-impact peer-reviewed journals on topics including immunotherapy, autoimmunity, adaptive, and innate immunity in humans. We also feature news on clinical trials, award announcements, and funding opportunities.
