Hematopoiesis News
Hematopoiesis News is an online resource that provides updates on the latest research in the fields of hematopoiesis, blood, and bone marrow disorders.
Modeling GATA2 Deficiency in Mice: The R396Q Mutation Disrupts Normal Hematopoiesis
[Leukemia] While mutant mice exhibited mild defects in peripheral blood, they displayed significant hematopoietic abnormalities in the bone marrow, including a reduction in hematopoietic stem cell function and intrinsic biases toward specific stem cell subsets that differed from previous models of GATA2 loss.
High Frequency CCR5 Editing in Human Hematopoietic Stem Progenitor Cells Protects Xenograft Mice from HIV Infection
[Nature Communications] Scientists showed the application of CRISPR/Cas9 to achieve >90% CCR5 editing in human, mobilized hematopoietic stem progenitor cells, resulting in a transplant that underwent normal hematopoiesis, produced CCR5 null T cells, and rendered xenograft mice refractory to HIV infection.
Hyper-CVAD and Sequential Blinatumomab Without and With Inotuzumab in Young Adults With Newly Diagnosed Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia
[American Journal of Hematology] Patients with newly diagnosed B-cell acute lymphoblastic leukemia received up to four cycles of hyper-CVAD followed by four cycles of blinatumomab. Inotuzumab ozogamicin 0.3 mg/m2 was added on days one and eight to two cycles of high-dose methotrexate and cytarabine, and two cycles of blinatumomab.
Deciphering the Effect of UM171 on Human Hematopoietic Progenitor Cell Fate Through Clonal Analysis
[Nature Communications] In addition to its HSC self-renewing property, scientists reported that UM171 specifically modulated cell fate of a precursor common to erythroid, megakaryocytic, and mast cells in favor of self-renewal and a mast-bias differentiation trajectory.
Global Trial Finding a Cure for Rare Childhood Cancer Opens
[University of Birmingham] A global trial has opened for children who have not responded to treatment for B-cell Non-Hodgkin Lymphoma, or who have relapsed.
FLI1 and GATA1 Govern TLN1 Transcription: New Insights into FLI1-Related Platelet Disorders
[Haematologica] Focusing on four FLI1 variants, two of which were novel, investigators assessed the impact of FLI1 variants on megakaryopoiesis using single-cell RNA sequencing. Defects were confirmed in patient platelets and cell lines.
Transplant and Nontransplant Salvage Therapy in Pediatric Relapsed or Refractory Hodgkin Lymphoma
[Jama Oncology] In this nonrandomized clinical trial, 59 patients with low-risk disease were identified, of which 41 received transplant-free salvage with a five-year progression-free survival (PFS) of 89.7%, and 18 received high-dose chemotherapy/autologous stem cell transplantoff protocol with a five-year PFS of 88.9%.
Reducing Functionally Defective Old HSCs Alleviates Aging-Related Phenotypes in Old Recipient Mice
[Cell Research] Through comprehensive molecular and functional analyses, scientists identified a subset of hematopoietic stem cells in aged mice that exhibited “younger” molecular profiles and functions, marked by low levels of CD150 expression.
Enhanced Engraftment of Human Hematopoietic Stem Cells via Mechanical Remodelling Mediated by the Corticotropin-Releasing Hormone
[Nature Biomedical Engineering] Scientists reported the role of the corticotropin-releasing hormone in enhancing the homing and engraftment of human-cord-blood hematopoietic stem and progenitor cells in bone marrow through mechanical remodelling.
A Phase 2 Pilot Study of Umbilical Cord Blood Infusion as an Adjuvant Consolidation Therapy in Elderly Patients with Acute Myeloid Leukemia
[Signal Transduction and Targeted Therapy] Investigators conducted a prospective, Phase II, single-arm trial of umbilical cord blood infusion as an adjuvant consolidation therapy in elderly AML patients.
Dietary Methionine Supplementation Promotes Mice Hematopoiesis After Irradiation
[Military Medical Research] Scientists screened out the key amino acids that regulated hematopoietic reconstitution in the bone marrow by analyzing the changes in amino acids. They provided a theoretical basis for the treatment strategy of hematopoietic reconstruction after radiation.
Inflammasomes: Potential Therapeutic Targets in Hematopoietic Stem Cell Transplantation
[Cell Communication and Signaling] Researchers examine the molecular architecture and composition of various types of inflammasomes, highlighting their activation and effector mechanisms within the context of the HSCT process and its associated complications.
Hematopoiesis News curates the top publications and reviews covering the regulation, expression patterns, differentiation and characterization of hematopoietic stem cells, as well as blood and bone marrow disorders. We also feature the latest job postings and upcoming conferences in the hematopoiesis field.
