Extracellular Matrix News
Extracellular Matrix News is an online resource that keeps scientists updated on the latest extracellular matrix research.
Engineering Bone/Cartilage Organoids: Strategy, Progress, and Application
[Bone Research] Scientists discuss strategies for bone/cartilage organoid construction strategies, progresses in the research, and potential applications. They also delve into the significance of selecting appropriate cells, matrix gels, cytokines/inducers, and construction techniques.
Cell Response to Extracellular Matrix Viscous Energy Dissipation Outweighs High-Rigidity Sensing
[Science Advances] Researchers exploited engineered stiff viscoelastic protein hydrogels to show that, contrary to current models of cell-ECM interaction, substrate viscous energy dissipation attenuated mechanosensing even when cells were exposed to higher effective rigidity.
Matrix Architecture and Mechanics Regulate Myofibril Organization, Costamere Assembly, and Contractility in Engineered Myocardial Microtissues
[Advanced Science] Scientists established arrays of cardiac microtissues with tunable mechanics and architecture by integrating ECM-mimetic synthetic, fiber matrices, and induced pluripotent stem cell-derived cardiomyocytes, enabling real-time contractility readouts, in-depth structural assessment, and tissue-specific computational modeling.
Mineralized Collagen Plywood Contributes to Bone Autograft Performance
[Nature] Researchers demonstrated that a hierarchical hybrid microstructure—specifically, the twisted plywood pattern of collagen and its association with poorly crystallized bioapatite—favourably influenced bone regeneration.
Reconstructing the Stem Leydig Cell Niche via the Testicular Extracellular Matrix for the Treatment of Testicular Leydig Cell Dysfunction
[Advanced Science] Scientists developed a decellularized testicular extracellular matrix hydrogel from young pigs and evaluated its safety and feasibility as a supportive niche for the expansion and differentiation of stem Leydig cells.
KMT2A Regulates the Autophagy-GATA4 Axis Through METTL3-Mediated m6A Modification of ATG4a to Promote NPCs Senescence and IVDD Progression
[Bone Research] Investigators observed impaired autophagy in Iitervertebral disc degeneration-nucleus pulposus cells (NPCs), which contributed to the upregulation of NPCs senescence and the senescence-associated secretory phenotype.
FibroBiologics Files Patent Application Covering Reduction of Blood Clots Associated with Instant Blood-Mediated Inflammatory Reaction (IBMIR) in Cell-Based Therapeutics
[FibroBiologics, Inc.] FibroBiologics, Inc. announced the filing of a patent application with the United States Patent and Trademark Office covering methods employing fibroblasts or other Tissue Factor-expressing cells to prevent IBMIR-mediated blood clotting.
Sonoma Pharmaceuticals Receives New FDA 510(k) Clearance for Microcyn(R)-Based Wound Care Hydrogel
[Sonoma Pharmaceuticals, Inc.] Sonoma Pharmaceuticals, Inc. announced it has received a new 510(k) clearance from the US FDA for its Microcyn technology-based hydrogel, including improved biocompatibility and extended shelf life.
YAP Enhances Mitochondrial OXPHOS in Tumor-Infiltrating Treg through Upregulating Lars2 on Stiff Matrix
[Journal For Immunotherapy of Cancer] Alterations in stiffness were performed both in vitro and in vivo to gain insight into the effect of matrix stiffness on YAP activation in Tregs. Investigators reported that YAP, as a mechanotransducer, was activated by matrix stiffness in tumor-infiltrating regulatory T cells.
Collagen Formation, Function, and Role in Kidney Disease
[Nature Reviews Nephrology] A wide range of therapeutics are in development for collagen and kidney disorders, including genetic approaches, chaperone therapies, protein degradation strategies, and anti-fibrotic therapies.
Cell Adhesion and Local Cytokine Control on Protein-Functionalized PNIPAM-Co-AAc Hydrogel Microcarriers
[Small] Scientists introduced hydrogel particles co-polymerized from poly(N-isopropylacrylamide) (PNIPAM) and acrylic acid (AAc) as a platform technology for cell expansion. The resulting microcarriers exhibited an adjustable extracellular matrix-like softness, an adaptable gel charge, and functional carboxyl groups.
Matrix Metalloproteinase-Responsive Controlled Release of Self-Assembly Nanoparticles Accelerates Heart Valve Regeneration In Situ by Orchestrating Immunomodulation
[Advanced Science] Researchers introduced a matrix metalloproteinase (MMP)-response hydrogel system in which infiltrating immune cells produced the MMP to degrade hydrogel and engulfed nanoparticles to convert to anti-inflammatory phenotype.
The Extracellular Matrix News team is proud to provide an essential resource on the latest publications, reviews, industry news, and jobs relevant to the matrix research community. Topics include extracellular matrix-cell interactions, extracellular matrix protein characterization and their application in tissue engineering and regenerative medicine, and the development and characterization of synthetic scaffolds.
