Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Mineralized Collagen Plywood Contributes to Bone Autograft Performance
[Nature] Researchers demonstrated that a hierarchical hybrid microstructure—specifically, the twisted plywood pattern of collagen and its association with poorly crystallized bioapatite—favourably influenced bone regeneration.
KMT2A Regulates the Autophagy-GATA4 Axis Through METTL3-Mediated m6A Modification of ATG4a to Promote NPCs Senescence and IVDD Progression
[Bone Research] Investigators observed impaired autophagy in Iitervertebral disc degeneration-nucleus pulposus cells (NPCs), which contributed to the upregulation of NPCs senescence and the senescence-associated secretory phenotype.
Cell Therapy and the Skin: Great Potential but in Need of Optimization
[Journal of Investigative Dermatology] The use of fibroblasts and keratinocytes as cell therapy has shown promise in skin disorders such as epidermolysis bullosa. Future efforts include testing the ability of fibroblasts to reprogram nonvolar to volar skin to reduce stump dermatoses in patients with limb loss using prosthetics.
Novel Integrated Multiomics Analysis Reveals a Key Role for Integrin Beta-Like 1 in Wound Scarring
[EMBO Reports] Transgenic mouse experiments confirmed that Itgbl1-expressing fibroblasts were required for granulation tissue formation and drove fibrogenesis during skin repair. Scientists detected a minority population of Acta2high-expressing myofibroblasts with apparent involvement in scarring.
Rab7a Is an Enhancer of TPC2 Activity Regulating Melanoma Progression through Modulation of the GSK3β/β-Catenin/MITF-Axis
[Nature Communications] Scientists showed that the small hydrolyze guanosine triphosphate Rab7a strongly enhanced the activity of TPC2 and that effects of TPC2 on melanoma hallmarks, in vitro and in vivo strongly depended on the presence of Rab7a.
Bilayered Skin Equivalent Mimicking Psoriasis as Predictive Tool for Preclinical Treatment Studies
[Communications Biology] Scientists focused on treatment responses of 3D skin replicas. Cytokine-priming of skin organoids induced psoriatic features like inflammation, antimicrobial peptides, hyperproliferation, and impaired differentiation.
Mechanistic Basis of Atypical TERT Promoter Mutations
[Nature Communications] Atypical telomerase reverse transcriptase promoter (TERTp) mutations occured with canonical driver mutations in large cancer cohorts and arose subclonally specifically on the TERTp driver mutant chromosome homolog of melanoma cells treated with UV light in vitro.
Deciphering Melanophagy: Role of the PTK2-ITCH-MLANA-OPTN Cascade on Melanophagy in Melanocytes
[Autophagy] The authors discovered a regulatory signaling cascade that controlled melanophagy in 3,4,5-trimethoxycinnamate thymol ester (TCTE)-treated melanocytes. They highlight role of the protein tyrosine kinase 2 (PTK2)-itchy E3 ubiquitin protein ligase (ITCH)-melan-A (MLANA)-optineurin (OPTN) cascade in orchestrating melanophagy progression.
Unveiling the Impact of Hypodermis on Gene Expression for Advancing Bioprinted Full-Thickness 3D Skin Models
[Communications Biology] Researchers leveraged 3D bioprinting technology to fabricate a full-thickness human skin equivalent with hypodermis. The collagen hydrogel-based structure provided a mimetic environment for skin cells to adhere, proliferate, and differentiate.
TIPE2 Inhibits Melanoma Progression Through MEK/ERK Signaling
[Scientific Reports] This study elucidated the mechanism of action of TNFAIP8-like 2 (TIPE2) in the development of melanoma. Overexpression of TIPE2 inhibited the proliferation of melanoma cells in vitro and even inhibited tumor formation in vivo.
Molecular Mechanisms of MAZ Targeting Up-Regulation of NDUFS3 Expression to Promote Malignant Progression in Melanoma
[Communications Biology] Investigators found that Myc-associated zinc-finger protein (MAZ) could target and regulate the transcription of NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 (NDUFS3), a core subunit of mitochondrial complex I, to enhance mitochondrial metabolism and thus promote malignant progression of melanoma.
Three Researchers at Uppsala University Receive ERC Synergy Grants
[Uppsala University] Three researchers at Uppsala University have been awarded European Research Council (ERC) Synergy Grants in the 2024 call. Their work wil help to develop and improve immunotherapy for the treatment of glioblastoma and malignant melanoma cancers.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
