Dermal Cell News
Dermal Cell News is an online resource highlighting the latest research about wound healing, skin disorders, and dermal cancers.
Antagonistic Roles for MITF and TFE3 in Melanoma Plasticity
[Cell Reports] Investigators showed that TFE3 expression drove the metastatic phenotype in melanoma cell lines and tumors. Deletion of TFE3 in microphthalmia-associated transcription factor (MITF)-low melanoma cell lines suppressed their ability to migrate and metastasize.
Dual Role of Interferon-Gamma in the Response of Melanoma Patients to Immunotherapy with Immune Checkpoint Inhibitors
[Molecular Cancer] The authors discuss the role of interferon-gamma (IFN-γ) in the response of melanoma patients to immune checkpoint inhibitors (ICIs) with respect to its positive influence and role in IFN-γ-related mechanisms of resistance to ICIs.
Age-Associated Modulation of TREM1/2-Expressing Macrophages Promotes Melanoma Progression and Metastasis
[Cancer Research] Researchers demonstrated that age engendered the development of an immunosuppressive tumor microenvironment, which was linked to phenotypes associated with melanoma metastasis. TREM1 inhibition decreased melanoma growth in young but not old mice, whereas TREM2 inhibition prevented lung metastasis in aged mice.
MCL‑1 Safeguards Activated Hair Follicle Stem Cells to Enable Adult Hair Regeneration
[Nature Communications] To investigate the role of MCL‑1, a BCL‑2 family protein with anti‑apoptotic and apoptosis‑unrelated functions, researchers deleted Mcl‑1 within the skin epithelium using constitutive and inducible systems.
OPM Announces Protocol Submission for Its Phase Ib/IIa Study, REVERT for OPM-101 in Combination with Pembrolizumab in Patients with Advanced Melanoma Resistant to Anti-PD1
[OPM] Oncodesign Precision Medicine (OPM) announced the submission to Swiss authorities of the study protocol for its Phase Ib/IIa clinical trial REVERT with OPM-101, its RIPK2 inhibitor in advanced melanoma patients with resistance to anti-PD-1.
Plant Essential Oil Targets TRPV3 for Skin Renewal and Structural Mechanism of Action
[Nature Communications] Researchers reported that citronellal, a plant-derived acyclic monoterpene commonly used for personal care, stimulated skin renewal by promoting keratinocyte proliferation through the activation of transient receptor potential vanilloid 3 (TRPV3).
Kit-Mediated Autophagy Suppression Driven by a Viral Oncoprotein Emerges As a Crucial Survival Mechanism in Merkel Cell Carcinoma
[Autophagy] Investigators demonstrated that truncated MCPyV-encoded large T-antigen (suppressed macroautophagy/autophagy by stabilizing and sequestering KIT in the paranuclear compartment via binding VPS39.
Innovative Strategies for the Discovery of New Drugs against Androgenetic Alopecia
[Expert Opinion On Drug Discovery] Scientists outline relevant preclinical models, such as hair follicle cell cultures, 3D spheroids, organoids, follicle explants, and animal models, highlighting their advantages and limitations in androgenetic alopecia research.
The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma
[Clinical Cancer Research] Scientists performed single-cell transcriptome sequencing on multiple paired tissue sites from five patients diagnosed with melanoma arising in congenital melanocytic nevi, identifying four distinct states of melanocyte subpopulations during the progression from nevi to melanoma.
Implication of Immunobiological Function of Melanocytes in Dermatology
[Clinical Reviews In Allergy & Immunology] The authors highlight the diverse immunobiological functions of melanocytes and their implications in dermatology.
Human Scalp Hair Follicles Can “Taste”: Chemosensory Signaling via the Bitter Taste Receptor, TAS2R4, Inhibits Hair Growth Ex Vivo
[British Journal of Dermatology] Scientists uncovered that human scalp hair follicles engaged in chemosensation via bitter taste receptorsto regulate their growth, matrix keratinocyte proliferation, growth factor production, and overall gene expression.
Mechanistic Insights Into 5′-tiRNA-His-GTG Mediated Activation of the JNK Pathway in Skin Photoaging
[Aging Cell] Investigators found that in both photoaging cell models and the skin of photoaging mice, the 5′-tiRNA-His-GTG expression levels were significantly elevated.
As the largest organ in the human body, the skin is implicated in a wide range of health conditions. Dermal Cell News is dedicated to covering it all. Our website, newsletter, and Twitter feed highlight research on tissue regeneration in the treatment of skin wounds, burns, cancers, and disorders. We also feature relevant job postings and upcoming events.
