Cell Therapy News
Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.
The Clinical Landscape of CAR NK Cells
[Experimental Hematology & Oncology] The authors explore the current clinical landscape of CAR NK cells, and their application in hematologic malignancies and solid cancers, as well as their potential for treating autoimmune disorders.
Clinical Development of Therapeutic mRNA Applications
[Molecular Therapy] Researchers discuss examples of mRNA therapeutics currently in clinical trials within each category, providing a comprehensive overview of the field's progress and highlighting key advancements as of the end of 2024.
Optimization of Adeno-Associated Viral (AAV) Gene Therapies Vectors for Balancing Efficacy, Longevity, and Safety for Clinical Application
[Gene Therapy] Researchers sought to optimize a novel, CpG-rich AAV8 vector, referred to as pVR59, designed for treating lipoprotein lipase deficiency.
CAR T or NK Cells Targeting Mismatched HLA-DR Molecules in Acute Myeloid Leukemia after Allogeneic Hematopoietic Stem Cell Transplant
[Nature Cancer] Investigators identified KG2032 as a monoclonal antibody specifically bound to acute myeloid leukemia cells in about half of patients, but not to normal leukocytes other than B lymphocytes.
Intranasal Prime-Boost RNA Vaccination Elicits Potent T Cell Response for Lung Cancer Therapy
[Signal Transduction and Targeted Therapy] Researchers developed a non-invasive intranasal cancer vaccine utilizing circular RNA encapsulated in lipid nanoparticles to induce localized mucosal immune responses.
Lupus Research Alliance Grants Inaugural Awards to 11 Researchers Focused on Engineered Cell Therapies for Lupus
[Lupus Research Alliance] The Lupus Research Alliance announced the inaugural recipients of the new Targeted Research Program on Engineered Cell Therapies for Lupus (TRP-ECT) to support the development and mechanistic understanding of safe and accessible next-generation engineered cell therapies for people with lupus.
Peptide-Oligonucleotide Nanohybrids Designed for Precise Gene Therapy of Rheumatoid Arthritis
[Advanced Materials] A novel kind of engineered peptide and oligonucleotide nanohybrids were designed and fabricated, which provide various advantages including good biosafety, inflammatory region-targeted delivery, cell membrane penetration, reactive oxygen species scavenging, and endolysosomal escape.
Cas12a-Knock-In Mice for Multiplexed Genome Editing, Disease Modeling, and Immune-Cell Engineering
[Nature Biomedical Engineering] Scientists described a series of knock-in mice with a C57BL/6 background and with the conditional or constitutive expression of LbCas12a or of high-fidelity enhanced AsCas12a, which were inserted at the Rosa26 locus.
T Cell Receptor Precision Editing of Regulatory T Cells for Celiac Disease
[Science Translational Medicine] The authors showed that engineered regulatory T cells modified to orthotopically express T cell receptors specific to gluten peptides could quiet gluten-reactive effector T cells in vitro and in vivo.
CD24-Targeted CAR-T Cells Mediated Long-Term Anti-Tumor Efficacy through Activation of Endogenous Tumor Immune Responses
[Molecular Cancer Therapeutics] Scientists reported that CAR-T cells targeting CD24, a potential tumor biomarker and an innate immune checkpoint molecular, evoked robust anti-tumor efficacy and elicited long-term tumor regression.
VDAC2 Loss Elicits Tumor Destruction and Inflammation for Cancer Therapy
[Nature] Using complementary in vivo and in vitro CRISPR–Cas9 genetic screens to target metabolic factors, scientists established voltage-dependent anion channel 2 (VDAC2) as an immune signal-dependent checkpoint that curtailed interferon-γ (IFNγ)-mediated tumor destruction and inflammatory reprogramming of the tumor microenvironment.
Cell Therapy for Liver Disorders: Past, Present, and Future
[Nature Reviews Gastroenterology & Hepatology] Scientists focus on the advantages and drawbacks of distinct cell sources and the relative strategies to address different therapeutic needs in distinct liver diseases.
Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.
