Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Suppression of Cancer Stem-Like Cell Radioresistance by Inhibiting AMPK Signaling
[Journal of Radiation Research] Researchers investigated the potential efficacy of the pan-adenosine monophosphate-activated protein kinase inhibitor dorsomorphin in preventing CSC radioresistance.
Qingre Huayu Jianpi Decoction Suppresses Colorectal Tumorigenesis by Inhibiting Cancer Stem Cells and Cancer-Associated Fibroblasts
[Journal of Ethnopharmacology] Scientists evaluated the preventive and therapeutic effects of Qingre Huayu Jianpi decoction on colon cancer, particularly focusing on its impact on colon CSC proliferation and cancer-associated fibroblast activation.
Novel Strategy to Target Glioblastoma-Initiating Cells Using a Braintropic Adeno-Associated Virus Carrying a miR-Dependent Genome-Editing System
[British Journal of Cancer] Investigators developed a novel method that specifically eradicates glioblastoma-initiating cells with reducing side effects.
FAO-fueled OXPHOS and NRF2-mediated stress resilience in MICs drive lymph node metastasis
[Proceedings of The National Academy of Sciences of The United States of America] Researchers highlighted the pivotal roles of fatty acid oxidation-fueled oxidative phosphorylation (OXPHOS) and NRF2 in LN metastasis and suggested targeting these pathways as a promising therapeutic strategy for metastatic esophageal squamous cell carcinoma.
Epigenetic Mechanisms Controlling Human Leukemia Stem Cells and Therapy Resistance
[Nature Communications] Investigators applied functional genomic profiling to diverse human leukemias, including high-risk MLL- and NUP98-rearranged specimens, using label tracing in vivo.
Photothermal Treatment of Prostate Tumor with Micellar Indocyanine Green and Napabucasin to Co-Ablate Cancer Cells and Cancer Stem Cells
[Journal of Controlled Release] Scientists presented micellar indocyanine green and napabucasin that co-ablated cancer cells and cancer stem cells via photothermal therapy for the treatment of prostate tumors.
Inhibition of DNA Polymerase Eta-Mediated Translesion DNA Synthesis with Small Molecule Sensitises Ovarian Cancer Stem-Like Cells to Chemotherapy
[British Journal of Pharmacology] Researchers screened and identified chrysin as a small-molecule inhibitor that sensitized ovarian cancer stem-like cells to cisplatin treatment by inhibiting DNA polymerase eta-mediated translesion DNA synthesis.
Efficient and Discriminative Isolation of Circulating Cancer Stem Cells and Non-Stem-like Circulating Tumor Cells Using a Click-Handle-Loaded M13 Phage-Based Surface
[Analytical Chemistry] Investigators developed a novel circulating tumor cell isolation approach that integrates cell metabolic chemical tagging with a click-handle-loaded M13 phage-based surface (CHPhace).
ABCB1 Confers Resistance to Carboplatin by Accumulating Stem-Like Cells in the G2/M Phase of the Cell Cycle in P53null Ovarian Cancer
[Cell Death Discovery] Researchers demonstrated that acquired resistance to carboplatin in SKOV3 harboring a p53null mutation, but not in OVCAR3 with a p53R248Q, induced a significant portion of cells accumulated in the G2/M phase of the cell cycle, where cells highly expressed stemness marker with elevated proliferative capacity, which they believed was reversed by ABCB1 inhibition to the levels observed in non-resistant parental cells.
Immune Checkpoints Regulate Acute Myeloid Leukemia Stem Cells
[Leukemia] The authors summarized recent data on selected immune checkpoints of the immunoglobulin superfamily and the tumor necrosis factor receptor superfamily that have a documented role in the regulation of leukemia stem cells, independent of their immune regulatory role, and might become novel therapeutic targets.
AccuStem Sciences to Offer its MSC Blood Test to Lung Cancer Screening Programs in the United States
[AcuStem Sciences, Inc.] AccuStem Sciences, Inc. announced plans to launch its microRNA Signature Classifier (MSC) blood test for use in the more than 1.6 million US patients diagnosed each year with nodules as part of current lung cancer screening protocols.
High-Purity CTC RNA Sequencing Identifies Prostate Cancer Lineage Phenotypes Prognostic for Clinical Outcomes
[Cancer Discovery] Using a novel circulating tumor cell (CTC) isolation approach, researchers collected 273 CTC samples from 117 patients with metastatic prostate cancer for RNA sequencing.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
