Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
Tumor Evolution and Microenvironment Interactions in 2D and 3D Space
[Nature] To study the spatial interactions among cancer and non-cancer cells, researchers examined a cohort of 131 tumor sections from 78 cases across 6 cancer types by Visium spatial transcriptomics.
Self-Assembled Aldehyde Dehydrogenase-Activatable Nano-Prodrug for Cancer Stem Cell-Enriched Tumor Detection and Treatment
[Nature Communications] Scientists reported a self-assembled nano-prodrug composed of aldehyde dehydrogenases activatable photosensitizer and disulfide-linked all-trans retinoic acid for diagnosis and targeted treatment of CSCs enriched tumors.
Profiling Phenotypic Heterogeneity of Circulating Tumor Cells through Spatially Resolved Immunocapture on Nanoporous Micropillar Arrays
[ACS Nano] Researchers enabled highly efficient capture and in situ phenotypic analysis of circulating tumor cells through enhanced and tunable on-chip immunoaffinity binding.
Computational Investigations of Flavonoids As ALDH Isoform Inhibitors for Treatment of Cancer
[Sar and Qsar In Environmental Research] Scientists evaluated 830 flavonoids from the PubChem database against five ALDH isoforms using computational methods to identify potent inhibitors against cancer stem cell protection and maintenance.
Novel Pharmacologic Inhibition of Lysine-Specific Demethylase 1 as a Potential Therapeutic for Glioblastoma
[Cancer Gene Therapy] Investigators reported the development of an lysine-specific demethylase (LSD) inhibitor, S2172, which efficiently penetrated the blood-brain barrier. S2172 effectively suppresses LSD1 enzymatic activity, resulting in the depletion of cell growth both in vitro and in vitro models of glioma stem cells.
PIWIL2/PDK1 Axis Promotes the Progression of Cervical Epithelial Lesions via Metabolic Reprogramming to Maintain Tumor-Initiating Cell Stemness
[Advanced Science] Researchers revealed that aberrant pyruvate dehydrogenase kinase 1 (PDK1) expression was closely related to aerobic glycolysis in squamous intraepithelial lesions and poor survival in patients with cervical cancer.
Deciphering the Topological Landscape of Glioma Using a Network Theory Framework
[Scientific Reports] The authors employed a systemic theoretical perspective to integrate experimental knowledge into a core endogenous network model for glioma, thereby elucidating its energy landscape through network dynamics computation. The model identifies two stable states corresponding to astrocytic-like and oligodendrocytic-like tumor cells.
Cutting-Edge Insights into Helicobacter Research
[Free Radical Research] The eradication of H. pylori reduces gastric cancer risk, but post-eradication surveillance is essential. Understanding the fundamental mechanisms of gastric carcinogenesis, including the roles of oxidative stress and cancer stem cells, is key to advancing treatment.
Io Therapeutics, Inc., Announces Presentation of Data on Its RAR Gamma Agonist Compound IRX5010 Demonstrating Inhibition of Tumor Infiltrating Myeloid Derived Suppressor Cells, Promotion...
[Io Therapeutics, Inc. (Globe Newswire)] Io Therapeutics, Inc., presented results from studies done in breast, colorectal, and prostate cancer models with the company’s newest anti-cancer compound IRX5010, an agonist of the retinoic acid nuclear receptor gamma, which was discovered in the company’s oncology drug program.
Self-Assembled Aldehyde Dehydrogenase-Activatable Nano-Prodrug for Cancer Stem Cell-Enriched Tumor Detection and Treatment
[Nature Communications] Scientists reported a self-assembled nano-prodrug composed of aldehyde dehydrogenases activatable photosensitizer and disulfide-linked all-trans retinoic acid for diagnosis and targeted treatment of CSCs enriched tumors.
Polyclonality Overcomes Fitness Barriers in Apc-Driven Tumorigenesis
Investigators combined multicolor lineage tracing with chemical mutagenesis in mice to show that a large proportion of intestinal tumours have a multiancestral origin. Polyclonal...
EVA1-Antibody Drug Conjugate Is a New Therapeutic Strategy for Eliminating Glioblastoma-Initiating Cells
[Neuro-Oncology] Hybridoma cells were generated by immunizing BALB/c mice with EVA1-Fc fusion protein. The reactivity of the supernatant from these hybridoma cells was examined using EVA1-overexpressing cells and glioblastoma-initiating cells. Candidate antibodies were further selected using Biacore surface plasmon resonance analysis and two cytotoxicity assays, antibody-dependent cell cytotoxicity and complement-dependent cytotoxicity
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
