Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
DMC-BH Derivative DMC-GF Inhibits the Growth of Glioma Stem Cells by Targeting the TRIM33/SLC25A1/Mitochondrial Oxidative Phosphorylation Pathway
[Journal of Translational Medicine] Investigators developed DMC-GF, a novel GLUT1-based curcumin derivative, to enhance brain specificity and metabolic stability compared to its predecessor DMC-BH.
Clusterin-Mediated Polarization of M2 Macrophages: A Mechanism of Temozolomide Resistance in Glioblastoma Stem Cells
[Stem Cell Research & Therapy] Scientists investigated a novel resistance mechanism involving glioblastoma stem cells and the polarization of M2-type macrophages, mediated by the extracellular vesicle-based transfer of Clusterin.
Targeting the AKT/mTOR Pathway Attenuates the Metastatic Potential of Colorectal Carcinoma Circulating Tumor Cells in a Murine Xenotransplantation Model
[Molecular Oncology] The susceptibility of the colon cancer circulating tumor cell (CTC)-derived cell line CTC-MCC-41 to AKT and mammalian target of rapamycin (mTOR) inhibitors was evaluated.
Multi-Omic Analyses Reveal Aberrant DNA Methylation Patterns and the Associated Biomarkers of Nasopharyngeal Carcinoma and Its Cancer Stem Cells
[Scientific Reports] The authors integratively performed DNA methylome and transcriptome combined with single-nucleus RNA sequencing to investigate DNA methylation and gene expression patterns of nasopharyngeal carcinoma and CSCs.
Role of Octamer Transcription Factor 4 in Proliferation, Migration, Drug Sensitivity, and Stemness Maintenance of Pancreatic Cancer Cells
[World Journal of Clinical Oncology] Scientists investigated the role of Octamer transcription factor 4 in pancreatic CSCs and its effect on pancreatic cancer cell proliferation, migration, drug sensitivity, and stemness maintenance.
Role of Noncoding RNA As a Pacemaker in Cancer Stem Cell Regulation: A Review Article
[Journal of the Egyptian National Cancer Institute] The authors provide insight into how noncoding RNAs regulate CSCs and how this correlation is manipulated to develop new therapies to eradicate cancer cells successfully.
Windsor Hospital’S New Linear Accelerator Will Expand Cancer Treatment Capacity
[CBC News] A new machine at Windsor Regional Hospital could help deliver 26,000 more cancer treatments a year. The hospital's new linear accelerator is a new, state-of-the-art machine that delivers targeted radiation treatments to people with cancer.
MAGL Targeted PROTAC Degrader Simultaneously Enhances P53 for Synergistic Treatment of Glioblastoma Stem Cell
[Cell Death Discovery] Researchers presented a proof-of-concept PROTAC design tailored for glioblastoma (GBM) stem cells, potentially addressing the occurrence challenges for GBM.
PNO1 Enhances Ovarian Cancer Cell Growth, Invasion, and Stemness via Activating the AKT/Wnt/β-catenin Pathway
[Scientific Reports] The authors demonstrated that PNO1 silencing markedly reduced the proliferation and invasion capabilities of ovarian cancer cell lines, triggering their apoptosis.
Unraveling the Triad of Hypoxia, Cancer Cell Stemness, and Drug Resistance
[Journal of Hematology & Oncology] Investigators elucidate the interplay between hypoxia and CSCs, as well as their correlation with resistance to therapeutic drugs.
PHGDH Activation Fuels Glioblastoma Progression and Radioresistance via Serine Synthesis Pathway
[Journal of Experimental & Clinical Cancer Research] In silico analysis of glioblastoma patient data assessed serine synthesis pathway enrichment and phosphoglycerate dehydrogenase (PHGDH) expression linked with tumor stemness.
A Positive Feedback Loop of OTUD1 and C-Jun Driven by Leptin Expedites Stemness Maintenance in Ovarian Cancer
[Oncogene] The deubiquitinase OTUD1 was identified as a critical regulator of leptin in maintaining ovarian CSCs properties.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
