Laurisa Dohm

Dermal Cell News

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

[Nano Letters] The authors highlight the current state of the art in nanozyme-engineered hydrogels for anti-inflammatory and skin regeneration applications.

Dermal Cell News

Adipose-Derived Stem Cells in Immune-Related Skin Disease: A Review of Current Research and Underlying Mechanisms

[Stem Cell Research & Therapy] The authors review the mechanisms underlying the immunomodulatory effects of adipose-derived stem cells, as well as progress in research on immune-related skin diseases.

Dermal Cell News

Activating Autophagy Promotes Skin Regeneration Induced by Mechanical Stretch during Tissue Expansion

[Burns & Trauma] Activating autophagy accelerated skin regeneration during tissue expansion by enhancing the proliferation of cells and the number of epidermal basal and hair follicle stem cells, reducing apoptosis, improving angiogenesis, and promoting collagen synthesis and growth factor secretion.

Dermal Cell News

Androgen Drives Melanoma Invasiveness and Metastatic Spread by Inducing Tumorigenic Fucosylation

[Nature Communications] Global phosphoproteomic and fucoproteomic profiling, coupled with in vitro and in vivo functional validation, further revealed that anfrogen receptor-induced FUT4 fucosylates L1 cell adhesion molecule, which was required for FUT4-increased metastatic capacity.

Dermal Cell News

Development of Tight Junction-Strengthening Compounds Using a High-Throughput Screening System to Evaluate Cell Surface-Localized Claudin-1 in Keratinocytes

[Scientific Reports] To obtain compounds that can improve tight junction function, scientists developed a novel high-throughput screening system termed live-cell immunostaining to evaluate cell surface-localized claudin-1 with high selectivity using normal human epidermal keratinocytes.

Hematopoiesis News

Utility of Allogeneic Stem Cell Transplantation for Adult Ph+ALL eith Complete Molecular Remission

[American Journal Of Hematology] Researchers compared the outcomes between Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) patients who did or did not undergo allogeneic stem cell transplantation in the first complete remission.

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A PSMA-Targeted Tri-Specific Killer Engager Enhances NK Cell Cytotoxicity Against Prostate Cancer

[Cancer Immunology Research] Scientists reported that the prostate-specific membrane antigen (PSMA) Tri-specific Killer Engager specifically bound to PSMA-expressing cells and significantly enhanced expansion, degranulation, and cytokine production of NK cells derived from healthy donors or prostate cancer patients.

Osteoblast-Derived ECM1 Promotes Anti-Androgen Resistance in Bone Metastatic Prostate Cancer

[Advanced Science] Researchers demonstrated that under enzalutamide treatment, osteoblasts in the bone microenvironment secrete increased levels of extracellular matrix protein 1 (ECM1), which affected surrounding prostate cancer cells, promoting tumor cell proliferation and anti-androgen resistance.

Rapid Modulation of Striatal Cholinergic Interneurons and Dopamine Release by Satellite Astrocytes

[Nature Communications] Scientists discovered that striatal astrocytes occupied a cell type-specific anatomical and functional relationship with cholinergic interneurons (ChIs), through which they rapidly excited ChIs and governed dopamine release via nicotinic acetylcholine receptors on subsecond timescales.

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Laurisa Dohm

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